Rabbit OAT Polyclonal Antibody | anti-OAT antibody

OAT Antibody

Cat. Num. AAA9403942

• Gene Names: OAT; OKT; GACR; HOGA; OATASE
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: OAT; Polyclonal Antibody; OAT Antibody; DKFZp781A11155; GACR; gyrate atrophy; HOGA; anti-OAT antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total OAT protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 439

• Applicable Applications for anti-OAT antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from Internal of human OAT.
• Target Name: OAT
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from K562/COLO205 cells, using OAT antibody.)

Related Product Information for anti-OAT antibody

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome.ana G., Proc. Natl. Acad. Sci. U.S.A. 83:1203-1207(1986).Ramesh V., DNA 5:493-501(1986).

Product Categories/Family for anti-OAT antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4557809
• NCBI GeneID: 4942
• NCBI Accession #: NP_000265.1
• NCBI GenBank Nucleotide #: NM_000274.3
• UniProt Accession #: P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0
• Molecular Weight: 32,853 Da
• NCBI Official Full Name: ornithine aminotransferase, mitochondrial isoform 1
• NCBI Official Synonym Full Names: ornithine aminotransferase
• NCBI Official Symbol: OAT
• NCBI Official Synonym Symbols: OKT; GACR; HOGA; OATASE
• NCBI Protein Information: ornithine aminotransferase, mitochondrial
• UniProt Protein Name: Ornithine aminotransferase, mitochondrial
• UniProt Gene Name: OAT
• UniProt Entry Name: OAT_HUMAN

NCBI Description

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

Uniprot Description

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.6.1.13; Amino Acid Metabolism - arginine and proline; Transferase; Mitochondrial

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: visual perception; amino acid biosynthetic process

Disease: Gyrate Atrophy Of Choroid And Retina