Mouse anti-Human OAT Monoclonal Antibody | anti-OAT antibody

Mouse Monoclonal [clone AT23A2] (IgG1,k) to Human OAT

Cat. Num. AAA245833

• Gene Names: OAT; OKT; GACR; HOGA; OATASE
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein G Purified
• Synonyms: OAT; Monoclonal Antibody; Mouse Monoclonal [clone AT23A2] (IgG1; k) to Human OAT; Anti-OAT Antibody (clone AT23A2) IHC-plus; GACR; HOGA; OKT; Gyrate atrophy; OATASE; Ornithine aminotransferase; Human OAT; anti-OAT antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: AT23A2
• Specificity: Human OAT
• Purity/Purification: Protein G Purified
• Form/Format: Phosphate buffered saline, pH 7.4, 0.1% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 439

• Applicable Applications for anti-OAT antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Recombinant human OAT
• Immunogen Type: Recombinant protein
• Immunogen: OAT antibody was raised against recombinant human OAT
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-OAT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-OAT antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Related Product Information for anti-OAT antibody

OAT encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme is the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy.

NCBI and Uniprot Product Information

• NCBI GI #: 4557809
• NCBI GeneID: 4942
• NCBI Accession #: NP_000265.1
• NCBI GenBank Nucleotide #: NM_000274.3
• UniProt Accession #: P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0
• Molecular Weight: 32,853 Da
• NCBI Official Full Name: ornithine aminotransferase, mitochondrial isoform 1
• NCBI Official Synonym Full Names: ornithine aminotransferase
• NCBI Official Symbol: OAT
• NCBI Official Synonym Symbols: OKT; GACR; HOGA; OATASE
• NCBI Protein Information: ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine delta-aminotransferase; ornithine-oxo-acid aminotransferase
• UniProt Protein Name: Ornithine aminotransferase, mitochondrial
• UniProt Gene Name: OAT
• UniProt Entry Name: OAT_HUMAN

NCBI Description

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

Uniprot Description

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: visual perception; amino acid biosynthetic process

Disease: Gyrate Atrophy Of Choroid And Retina