Rabbit anti-Human OAT Polyclonal Antibody | anti-OAT antibody

OAT (Ornithine Aminotransferase, Ornithine delta-Aminotransferase, Ornithine-oxo-acid Aminotransferase, DKFZp781A11155, GACR, HOGA, OATASE, OKT) (Biotin)

Cat. Num. AAA6387889

• Gene Names: OAT; OKT; GACR; HOGA; OATASE
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: OAT; Polyclonal Antibody; OAT (Ornithine Aminotransferase; Ornithine delta-Aminotransferase; Ornithine-oxo-acid Aminotransferase; DKFZp781A11155; GACR; HOGA; OATASE; OKT) (Biotin); anti-OAT antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human OAT.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-OAT antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human OAT, aa1-439 (NP_000265.1).
• Immunogen Sequence: MFSKLAHFQRFAVLSRGVHSSVASATSVATKKTVQGPPTSDDIFEREYKYGAHNYHPLPVALERGKGIYLWDVEGRKYFDFLSSYSAVNQGHCHPKIVNALKSQVDKLTLTSRAFYNNVLGEYEEYITKLFNYHKVLPMNTGVEAGETACKLARKWGYTVKGIQKYKAKIVFAAGNFWGRTLSAISSSTDPTSYDGFGPFMPGFDIIPYNDLPALERALQDPNVAAFMVEPIQGEAGVVVPDPGYLMGVRELCTRHQVLFIADEIQTGLARTGRWLAVDYENVRPDIVLLGKALSGGLYPVSAVLCDDDIMLTIKPGEHGSTYGGNPLGCRVAIAALEVLEEENLAENADKLGIILRNELMKLPSDVVTAVRGKGLLNAIVIKETKDWDAWKVCLRLRDNGLLAKPTHGDIIRFAPPLVIKEDELRESIEIINKTILSF
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of OAT expression in transfected 293T cell line by OAT polyclonal antibody. Lane 1: OAT transfected lysate (48.5kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-OAT antibody

OAT is the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA.

Product Categories/Family for anti-OAT antibody

Antibodies; Enzymes; Aminotransferase

NCBI and Uniprot Product Information

• NCBI GI #: 4557809
• NCBI GeneID: 4942
• NCBI Accession #: NP_000265.1
• NCBI GenBank Nucleotide #: NM_000274.1
• UniProt Accession #: P04181; Q16068; Q16069; Q68CS0; Q6IAV9; Q9UD03; D3DRF0
• Molecular Weight: 48,535 Da
• NCBI Official Full Name: ornithine aminotransferase, mitochondrial isoform 1
• NCBI Official Synonym Full Names: ornithine aminotransferase
• NCBI Official Symbol: OAT
• NCBI Official Synonym Symbols: OKT; GACR; HOGA; OATASE
• NCBI Protein Information: ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine delta-aminotransferase; ornithine-oxo-acid aminotransferase
• UniProt Protein Name: Ornithine aminotransferase, mitochondrial
• UniProt Gene Name: OAT
• UniProt Entry Name: OAT_HUMAN

NCBI Description

This gene encodes the mitochondrial enzyme ornithine aminotransferase, which is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy. Alternatively spliced transcript variants encoding different isoforms have been described. Related pseudogenes have been defined on the X chromosome. [provided by RefSeq, Jan 2010]

Uniprot Description

OAT: Defects in OAT are the cause of hyperornithinemia with gyrate atrophy of choroid and retina (HOGA). HOGA is a slowly progressive blinding autosomal recessive disorder. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; Amino Acid Metabolism - arginine and proline; EC 2.6.1.13; Mitochondrial

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: ornithine-oxo-acid transaminase activity; pyridoxal phosphate binding

Biological Process: visual perception; amino acid biosynthetic process

Disease: Gyrate Atrophy Of Choroid And Retina