Goat anti-Human NUDC Polyclonal Antibody | anti-NUDC antibody

NUDC (Nuclear Distribution Gene C Homolog)

Cat. Num. AAA629865

• Gene Names: NUDC; HNUDC; MNUDC; NPD011
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by peptide affinity chromatography.
• Synonyms: NUDC; Polyclonal Antibody; NUDC (Nuclear Distribution Gene C Homolog); Anti -NUDC (Nuclear Distribution Gene C Homolog); anti-NUDC antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NUDC. Species sequence homology: mouse, rat, canine, bovine.
• Purity/Purification: Affinity Purified; Purified by peptide affinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-NUDC antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Peptide ELISA Titer: 1:32,000; Western Blot: 0.3-1ug/ml detects ~40kD band observed in lysates of cell line HeLa (calculated MW of 38.2kD according to NP_006591.1).
• Immunogen: Synthetic peptide corresponding to C-PNLGNGADLPNYR, from the internal region of human NUDC (NP_006591.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chemiluminescence

(MBS629865 (0.3ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-NUDC antibody

NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein.

Product Categories/Family for anti-NUDC antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 5729953
• NCBI GeneID: 10726
• NCBI Accession #: NP_006591.1
• NCBI GenBank Nucleotide #: NM_006600.3
• UniProt Accession #: Q9Y266; Q5QP31; Q5QP35; Q9H0N2; Q9Y2B6
• Molecular Weight: 38,243 Da
• NCBI Official Full Name: nuclear migration protein nudC
• NCBI Official Synonym Full Names: nudC nuclear distribution protein
• NCBI Official Symbol: NUDC
• NCBI Official Synonym Symbols: HNUDC; MNUDC; NPD011
• NCBI Protein Information: nuclear migration protein nudC; nuclear distribution C homolog; nuclear distribution gene C homolog; nuclear distribution protein C homolog
• UniProt Protein Name: Nuclear migration protein nudC
• Protein Family: NADH pyrophosphatase
• UniProt Gene Name: NUDC
• UniProt Entry Name: NUDC_HUMAN

NCBI Description

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

Uniprot Description

NUDC: a cytoskeletal protein that is a component of the dynactin complex. The cytoplasmic dynein/dynactin complex, a minus-end-directed motor, powers various) aspects of mitosis, including establishment of bipolarity, organization of spindle poles, alignment and segregation of chromosomes, as well as regulation of microtubule dynamics. Phosphorylation by PLK1 may play a critical role in cytokinesis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: nucleoplasm; microtubule; cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: mitosis; cell proliferation; cell division; multicellular organismal development; mitotic cell cycle