Rabbit anti-Human NUDC Polyclonal Antibody | anti-NUDC antibody

NUDC, ID (NUDC, Nuclear migration protein nudC, Nuclear distribution protein C homolog) (AP)

Cat. Num. AAA6327084

• Gene Names: NUDC; HNUDC; MNUDC; NPD011
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: NUDC; Polyclonal Antibody; ID (NUDC; Nuclear migration protein nudC; Nuclear distribution protein C homolog) (AP); Nuclear distribution protein C homolog; anti-NUDC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-NUDC antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: NUDC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the Central region of human NUDC.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(NUDC Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the NUDC antibody detected the NUDC protein (arrow).)

Related Product Information for anti-NUDC antibody

NudC was first identified as a regulator of nuclear movement in the asexual reproductive cycle of the filamentous fungus Aspergillus nidulans. Human NUDC is a nuclear movement protein that associates with dynein (see DYNC1H1; MIM 600112) (Aumais et al., 2003 [PubMed 12679384]).

Product Categories/Family for anti-NUDC antibody

Antibodies; Nuclear Proteins

References

Zhu, X.J., et al. J. Biol. Chem. 285(39):29903-29910(2010). Chen, W.M., et al. J. Biol. Chem. 285(34):26697-26709(2010). Pang, S.F., et al. Exp. Cell Res. 315(20):3563-3573(2009). Tang, Y.S., et al. Leukemia 22(5):1018-1025(2008). Zhang, Y.P., et al. Exp. Cell Res. 313(15):3210-3221(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 5729953
• NCBI GeneID: 10726
• NCBI Accession #: NP_006591.1
• NCBI GenBank Nucleotide #: NM_006600.3
• UniProt Accession #: Q9Y266; Q5QP31; Q5QP35; Q9H0N2; Q9Y2B6
• Molecular Weight: 38,243 Da
• NCBI Official Full Name: nuclear migration protein nudC
• NCBI Official Synonym Full Names: nuclear distribution C homolog (A. nidulans)
• NCBI Official Symbol: NUDC
• NCBI Official Synonym Symbols: HNUDC; MNUDC; NPD011
• NCBI Protein Information: nuclear migration protein nudC; nuclear distribution gene C homolog; nuclear distribution protein C homolog
• UniProt Protein Name: Nuclear migration protein nudC
• Protein Family: NADH pyrophosphatase
• UniProt Gene Name: NUDC
• UniProt Entry Name: NUDC_HUMAN

NCBI Description

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

Uniprot Description

NUDC: a cytoskeletal protein that is a component of the dynactin complex. The cytoplasmic dynein/dynactin complex, a minus-end-directed motor, powers various) aspects of mitosis, including establishment of bipolarity, organization of spindle poles, alignment and segregation of chromosomes, as well as regulation of microtubule dynamics. Phosphorylation by PLK1 may play a critical role in cytokinesis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: nucleoplasm; microtubule; cytoplasm; cytosol

Molecular Function: protein binding

Biological Process: cell proliferation; mitosis; cell division; multicellular organismal development; mitotic cell cycle