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Immunohistochemistry (IHC) (Anti-NTSR2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit NTSR2 / NTR2 Polyclonal Antibody | anti-NTSR2 antibody

Rabbit Polyclonal to Human NTSR2 / NTR2

Gene Names
NTSR2; NTR2
Reactivity
Gibbon, Human
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Rabbit (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
NTSR2 / NTR2; Polyclonal Antibody; Rabbit Polyclonal to Human NTSR2 / NTR2; Anti-NTSR2 / NTR2 Antibody (Internal) IHC-plus; NTSR2; Neurotensin NT2 receptor; Neurotensin receptor; type 2; NTR2; NT2 receptor; Neurotensin receptor 2; Neurotensin receptor type 2; NT-R-2; Human NTSR2; anti-NTSR2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gibbon, Human
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human NTSR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MLNR (69%).
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
410
Applicable Applications for anti-NTSR2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes
ELISA, IHC-P (10 - 12 ug/ml)
Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K.
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from internal region of human NTSR2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey, Mouse, Rat, Bovine, Rabbit (94%); Dog, Hamster, Panda, Pig (88%).
Immunogen Type
Synthetic peptide
Immunogen
NTSR2 / NTR2 antibody was raised against synthetic 16 amino acid peptide from internal region of human NTSR2. Percent identity with other species by BLAST analysis: Human, Gibbon, Marmoset (100%); Monkey, Mouse, Rat, Bovine, Rabbit (94%); Dog, Hamster, Panda, Pig (88%).
Antigen Modification
Internal
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-NTSR2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-NTSR2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-NTSR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-NTSR2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-NTSR2 antibody
NTR2, a Neurotensin Receptor, is primarily expressed in brain neurons and astrocytes. It is activated by neurotensin and by levocabastine, a histamine H1 antagonist.
Product Categories/Family for anti-NTSR2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,385 Da
NCBI Official Full Name
neurotensin receptor type 2
NCBI Official Synonym Full Names
neurotensin receptor 2
NCBI Official Symbol
NTSR2
NCBI Official Synonym Symbols
NTR2
NCBI Protein Information
neurotensin receptor type 2; NT-R-2; neurotensin receptor, type 2; levocabastine-sensitive neurotensin receptor
UniProt Protein Name
Neurotensin receptor type 2
Protein Family
UniProt Gene Name
NTSR2
UniProt Synonym Gene Names
NT-R-2; NTR2
UniProt Entry Name
NTR2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

Uniprot Description

NTSR2: neurotensin receptor 2

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; neurotensin receptor activity, G-protein coupled

Biological Process: regulation of membrane potential; cell surface receptor linked signal transduction; neuropeptide signaling pathway; sensory perception; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

Research Articles on NTSR2

Similar Products

Product Notes

The NTSR2 ntsr2 (Catalog #AAA242300) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human NTSR2 / NTR2 reacts with Gibbon, Human Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Rabbit (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's NTSR2 / NTR2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA, IHC-P (10 - 12 ug/ml) Usage: Immunohistochemistry with formalin-fixed paraffin-embedded tissues requires pretreatment with Proteinase K. Researchers should empirically determine the suitability of the NTSR2 ntsr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NTSR2 / NTR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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