Rabbit NTRK1 / TRKA / TRK A Polyclonal Antibody | anti-NTRK1 antibody

Rabbit Polyclonal to Human NTRK1 / TRKA / TRK A

Cat. Num. AAA242032

• Gene Names: NTRK1; MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: Affinity Purified
• Synonyms: NTRK1 / TRKA / TRK A; Polyclonal Antibody; Rabbit Polyclonal to Human NTRK1 / TRKA / TRK A; Anti-NTRK1 / TRKA / TRK A Antibody IHC-plus; NTRK1; Oncogene TRK; TrkA/NGF receptor; Tropomyosin-related kinase A; TRK; TRK1; Tyrosine kinase receptor; Tyrosine kinase receptor A; gp140trk; MTC; p140-TrkA; Trk-A; TRKA; Human NTRK1; TRK A; anti-NTRK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects ~140 kD TrkA. It does not cross-react with TrkB or TrkC.
• Purity/Purification: Affinity Purified
• Form/Format: PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.01% Thimerosal.
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 796

• Applicable Applications for anti-NTRK1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: IHC-P (5 ug/ml), IP, WB (0.5 - 4 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide surrounding amino acid 494 of human TrkA.
• Immunogen Type: Synthetic peptide
• Immunogen: NTRK1 / TRKA / TRK A antibody was raised against synthetic peptide surrounding amino acid 494 of human TrkA.
• Preparation and Storage: Long term: -70 degree C; Short term: -20 degree C

Immunohistochemistry (IHC)

(Anti-NTRK1 / TRKA antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of TRKA / TRK A antibody.)

Related Product Information for anti-NTRK1 antibody

NTRK1 (trkA), a Trk/Ror type protein kinase, is a high-affinity receptor for the nerve growth factor NGF. NTRK1 has been shown to regulate neural development and maintenance of neural network. Mutation in NTRK1 gene is responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive hereditary disorder characterized by recurrent episodic fever, anhidrosis (inability to sweat), absence of reaction to noxious stimuli, self-mutilating behavior, and mental retardation.

Product Categories/Family for anti-NTRK1 antibody

Family: Protein Kinase; Subfamily: Trk/Ror

NCBI and Uniprot Product Information

• NCBI GI #: 4585712
• NCBI GeneID: 4914
• NCBI Accession #: NP_002520.2
• NCBI GenBank Nucleotide #: NM_002529.3
• UniProt Accession #: P04629; P08119; Q15655; Q15656; Q5D056; Q5VZS2; Q7Z5C3; Q9UIU7; B2R6T5; B7ZM34
• Molecular Weight: 77,145 Da
• NCBI Official Full Name: high affinity nerve growth factor receptor isoform 2
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 1
• NCBI Official Symbol: NTRK1
• NCBI Official Synonym Symbols: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA
• NCBI Protein Information: high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein
• UniProt Protein Name: High affinity nerve growth factor receptor
• Protein Family: High affinity nerve growth factor receptor
• UniProt Gene Name: NTRK1
• UniProt Synonym Gene Names: MTC; TRK; TRKA; Trk-A
• UniProt Entry Name: NTRK1_HUMAN

NCBI Description

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

Uniprot Description

TrkA: a receptor tyrosine kinase of the Trk family. High affinity receptor for nerve growth factor, neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor. Known substrates include Shc, PI-3K, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system. Two splice variant isoforms have been described.

Protein type: Membrane protein, integral; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Trk family

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: cell surface; protein complex; late endosome membrane; integral to plasma membrane; early endosome; dendrite; cell soma; early endosome membrane; axon; late endosome; plasma membrane; cytoplasmic vesicle; receptor complex; endosome

Molecular Function: neurotrophin p75 receptor binding; neurotrophin binding; protein binding; nerve growth factor receptor activity; protein homodimerization activity; ephrin receptor binding; nerve growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: circadian rhythm; axon guidance; mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; olfactory nerve development; protein amino acid phosphorylation; positive regulation of synaptic transmission, glutamatergic; activation of NF-kappaB transcription factor; negative regulation of cell proliferation; response to radiation; sympathetic nervous system development; learning and/or memory; small GTPase mediated signal transduction; response to axon injury; negative regulation of neuron apoptosis; response to electrical stimulus; detection of temperature stimulus involved in sensory perception of pain; response to hydrostatic pressure; aging; response to nutrient levels; response to drug; phosphoinositide-mediated signaling; adenylate cyclase activation; Sertoli cell development; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of angiogenesis; positive regulation of programmed cell death; response to ethanol; phospholipase C activation; B cell differentiation; Ras protein signal transduction; positive regulation of Ras protein signal transduction; response to activity; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Thyroid Carcinoma, Familial Medullary; Insensitivity To Pain, Congenital, With Anhidrosis