Rabbit NTMT1 Polyclonal Antibody | anti-NTMT1 antibody

NTMT1 Polyclonal Antibody

Cat. Num. AAA2516361

• Gene Names: NTMT1; NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: NTMT1; Polyclonal Antibody; NTMT1 Polyclonal Antibody; NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A; anti-NTMT1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 223

• Applicable Applications for anti-NTMT1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human NTMT1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human tonsil tissue using NTMT1 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-NTMT1 antibody

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET.

Product Categories/Family for anti-NTMT1 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 74761281
• NCBI GeneID: 28989
• Molecular Weight: 15,896 Da
• NCBI Official Full Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
• NCBI Official Synonym Full Names: N-terminal Xaa-Pro-Lys N-methyltransferase 1
• NCBI Official Symbol: NTMT1
• NCBI Official Synonym Symbols: NRMT; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A
• NCBI Protein Information: N-terminal Xaa-Pro-Lys N-methyltransferase 1; N-terminal RCC1 methyltransferase; X-Pro-Lys N-terminal protein methyltransferase 1A; alpha N-terminal protein methyltransferase 1A; methyltransferase-like protein 11A
• UniProt Protein Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1
• Protein Family: N-terminal Xaa-Pro-Lys N-methyltransferase
• UniProt Gene Name: NTMT1
• UniProt Synonym Gene Names: C9orf32; METTL11A; NRMT; NRMT1; NTM1A
• UniProt Entry Name: NTM1A_HUMAN

NCBI Description

The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

Uniprot Description

METTL11A: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. Belongs to the methyltransferase superfamily. NTM1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein N-term; EC 2.1.1.244; Methyltransferase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein methyltransferase activity

Biological Process: N-terminal peptidyl-proline di-methylation; spindle organization and biogenesis; N-terminal peptidyl-alanine tri-methylation; chromosome segregation