Western Blot (WB)
(Anti-NTAL antibody, MBS176153, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LAT2, 37.8KD(162aa tag+ M1-A182)Lane 1: Recombinant Human LAT2 Protein 10ngLane 2: Recombinant Human LAT2 Protein 5ngLane 3: Recombinant Human LAT2 Protein 2.5ngLane 4: Recombinant Human LAT2 Protein 1.25ng )
Rabbit anti-Human NTAL Polyclonal Antibody | anti-LAT2 antibody
Anti-NTAL antibody
Gene Names
LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
Reactivity
Human
Applications
Western Blot
Purity
Immunogen affinity purified.
Synonyms
NTAL; Polyclonal Antibody; Anti-NTAL antibody; Linker for activation of T-cells family member 2; linker for activation of T cells family; member 2; HSPC046 antibody; LAB antibody; Lat2 antibody; Linker for activation of B cells antibody; Linker for activation of B-cells antibody; Linker for activation of T cells family member 2 antibody; Linker for activation of T cells transmembrane adaptor 2 antibody; Linker for activation of T-cells family member 2 antibody; Linker of Activated B cells antibody; Membrane associated adapter molecule antibody; Membrane-associated adapter molecule antibody; Non T Cell Activation Linker antibody; Non-T-cell activation linker antibody; NTAL_HUMAN antibody; WBSCR 5 antibody; Wbscr15 antibody; Williams Beuren syndrome chromosome region 15 antibody; Williams Beuren Syndrome chromosome region 5 antibody; Williams-Beuren syndrome chromosomal region 15 protein antibody; Williams-Beuren syndrome chromosomal region 5 protein antibody; WSCR5 antibody; anti-LAT2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
243
Applicable Applications for anti-LAT2 antibody
Western Blot (WB)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human NTAL (34-48aa KRSEKIYQQRSLRED).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-NTAL antibody, MBS176153, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LAT2, 37.8KD(162aa tag+ M1-A182)Lane 1: Recombinant Human LAT2 Protein 10ngLane 2: Recombinant Human LAT2 Protein 5ngLane 3: Recombinant Human LAT2 Protein 2.5ngLane 4: Recombinant Human LAT2 Protein 1.25ng )
Western Blot (WB)
(Anti-NTAL antibody, MBS176153, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human LAT2, 37.8KD(162aa tag+ M1-A182)Lane 1: Recombinant Human LAT2 Protein 10ngLane 2: Recombinant Human LAT2 Protein 5ngLane 3: Recombinant Human LAT2 Protein 2.5ngLane 4: Recombinant Human LAT2 Protein 1.25ng )
Related Product Information for anti-LAT2 antibody
Description: Rabbit IgG polyclonal antibody for Linker for activation of T-cells family member 2(LAT2) detection. Tested with WB in Human.
Background: LAT2(Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL, is a protein that in humans is encoded by the LAT2 gene. By genomic sequence analysis, Doyle et al.(2000) mapped the WBSCR5 gene to chromosome 7q11.23. They noted that the flanking genes are highly conserved between mouse and human. By immunoprecipitation and immunoblot analysis, Brdicka et al.(2002) found that NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Janssen et al.(2003) determined that phosphorylation of LAB is likely mediated by SYK upon B-cell receptor stimulation. Binding analysis indicated associations with GRB2, and, indirectly, with PLCG1 and PLCG2.
Background: LAT2(Linker for Activation of T Cells Family, Member 2), also known as LAB or NTAL, is a protein that in humans is encoded by the LAT2 gene. By genomic sequence analysis, Doyle et al.(2000) mapped the WBSCR5 gene to chromosome 7q11.23. They noted that the flanking genes are highly conserved between mouse and human. By immunoprecipitation and immunoblot analysis, Brdicka et al.(2002) found that NTAL associated with GRB2, SOS1, and GAB1 after B-cell receptor activation. Janssen et al.(2003) determined that phosphorylation of LAB is likely mediated by SYK upon B-cell receptor stimulation. Binding analysis indicated associations with GRB2, and, indirectly, with PLCG1 and PLCG2.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
12,255 Da
NCBI Official Full Name
Linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T cells family, member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
NCBI Protein Information
linker for activation of T-cells family member 2; non-T-cell activation linker; linker for activation of B-cells; membrane-associated adapter molecule; Williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosomal region 15 protein; linker for activation of T cells, transmembrane adaptor 2
UniProt Protein Name
Linker for activation of T-cells family member 2
Protein Family
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Description
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: mast cell granule; integral to membrane; plasma membrane; lipid raft
Molecular Function: protein binding; SH2 domain binding
Biological Process: B cell receptor signaling pathway; B cell activation; calcium-mediated signaling; innate immune response; mast cell degranulation
Research Articles on LAT2
Similar Products
Product Notes
The LAT2 lat2 (Catalog #AAA176153) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-NTAL antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NTAL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LAT2 lat2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NTAL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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