Immunohistochemistry (IHC)
Rabbit LAT2 / NTAL Polyclonal Antibody | anti-LAT2 / NTAL antibody
NTAL Antibody
Gene Names
LAT2; LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
Reactivity
Human, Monkey
Applications
ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Synonyms
LAT2 / NTAL; Polyclonal Antibody; NTAL Antibody; HSPC046; LAB; LAT2; Linker for activation of B cells; Membrane associated adapter molecule; Non T cell activation linker; WBSCR 5; Wbscr15 antibody; anti-LAT2 / NTAL antibody
Host
Rabbit
Reactivity
Human, Monkey
Clonality
Polyclonal
Form/Format
Affinity Purified
Concentration
0.54-0.72 ug/ul in antibody stabilization buffer (varies by lot)
Sequence Length
243
Applicable Applications for anti-LAT2 / NTAL antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:200
Western Blot: 1:500
ELISA: 1:10,000
Immunohistochemistry: 1:200
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 40-90 on LAT2 protein.
Expression
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
Molecular Function
SH2 domain binding
Structure
When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.
Subcellular Location
Cell membrane; Single-pass type III membrane protein
Preparation and Storage
-20 degree C for long term storage
Immunohistochemistry (IHC)
Immunohistochemistry (IHC)
Related Product Information for anti-LAT2 / NTAL antibody
Affinity Purified Linker for activation of T-cells family member 2 Antibody
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.
Product Categories/Family for anti-LAT2 / NTAL antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
12,255 Da
NCBI Official Full Name
linker for activation of T-cells family member 2
NCBI Official Synonym Full Names
linker for activation of T-cells family member 2
NCBI Official Symbol
LAT2
NCBI Official Synonym Symbols
LAB; NTAL; WSCR5; WBSCR5; HSPC046; WBSCR15
NCBI Protein Information
linker for activation of T-cells family member 2
UniProt Protein Name
Linker for activation of T-cells family member 2
UniProt Gene Name
LAT2
UniProt Synonym Gene Names
LAB; NTAL; WBS15; WBSCR15; WBSCR5
UniProt Entry Name
NTAL_HUMAN
NCBI Description
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
LAB: linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: integral to membrane; intracellular; lipid raft; mast cell granule; plasma membrane
Molecular Function: protein binding; SH2 domain binding
Biological Process: adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; mast cell degranulation
Research Articles on LAT2 / NTAL
Similar Products
Product Notes
The LAT2 / NTAL lat2 (Catalog #AAA540895) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NTAL Antibody reacts with Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's LAT2 / NTAL can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunohistochemistry: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the LAT2 / NTAL lat2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAT2 / NTAL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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