Western Blot (WB)
(Western Blot analysis in mouse brain tissue lysate using MBS623814. This demonstrates MBS623814 detected the NR4A2 protein (arrow).)
Rabbit anti-Human NR4A2 Polyclonal Antibody | anti-NR4A2 antibody
NR4A2, NT (Nuclear Receptor Subfamily 4 Group A Member 2, Orphan Nuclear Receptor NURR1, NURR1, TINUR, NURR1, Immediate-early Response Protein NOT, NOT, Transcriptionally Inducible Nuclear Receptor)
Purified by ammonium sulfate precipitation.
Purified by ammonium sulfate precipitation.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100
Western Blot (WB)
(Western Blot analysis in mouse brain tissue lysate using MBS623814. This demonstrates MBS623814 detected the NR4A2 protein (arrow).)
Western Blot (WB)
(Western Blot analysis in mouse brain tissue lysate using MBS623814. This demonstrates MBS623814 detected the NR4A2 protein (arrow).)
Western Blot (WB)
(Western Blot analysis in Hela cell line lysates (35ug/lane) using MBS623814. This demonstrates that MBS623814 detected the NR4A2 protein (arrow).)
Western Blot (WB)
(Western Blot analysis in Hela cell line lysates (35ug/lane) using MBS623814. This demonstrates that MBS623814 detected the NR4A2 protein (arrow).)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS623814 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS623814 for immunohistochemistry.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS623814 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS623814 for immunohistochemistry.)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis with Hela cells using MBS623814 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
Immunofluorescence (IF)
(Confocal immunofluorescent analysis with Hela cells using MBS623814 followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]
Uniprot Description
NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 2q22-q23
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; protein heterodimerization activity; steroid hormone receptor activity
Biological Process: positive regulation of catalytic activity; transcription initiation from RNA polymerase II promoter; response to inorganic substance; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; adult locomotory behavior; death; response to amphetamine; regulation of dopamine metabolic process; neuron migration; central nervous system projection neuron axonogenesis; dopamine biosynthetic process; signal transduction; response to insecticide; neuron maturation; post-embryonic development; habenula development; regulation of respiratory gaseous exchange; general adaptation syndrome; cellular response to extracellular stimulus; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; negative regulation of neuron apoptosis
Disease: Parkinson Disease, Late-onset
Research Articles on NR4A2
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Product Notes
The NR4A2 nr4a2 (Catalog #AAA623814) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NR4A2, NT (Nuclear Receptor Subfamily 4 Group A Member 2, Orphan Nuclear Receptor NURR1, NURR1, TINUR, NURR1, Immediate-early Response Protein NOT, NOT, Transcriptionally Inducible Nuclear Receptor) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NR4A2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500 Immunohistochemistry: 1:50-1:100. Researchers should empirically determine the suitability of the NR4A2 nr4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NR4A2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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