Testing Data
(Image: Nurr1 staining of rat adult hippocampus. Tissue was fixed in paraformaldehyde and cut in 20 micron sections. Dulution 1:100.)
anti-Mouse, Rat Nurr1 Antibody | anti-Nurr1 antibody
Nurr1, Affinity Purified Antibody, Rabbit
Testing Data
(Image: Nurr1 staining of rat adult hippocampus. Tissue was fixed in paraformaldehyde and cut in 20 micron sections. Dulution 1:100.)
Testing Data
(Image: Nurr1 staining of rat adult hippocampus. Tissue was fixed in paraformaldehyde and cut in 20 micron sections. Dulution 1:100.)
The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's.
Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.
NCBI and Uniprot Product Information
Uniprot Description
NR4A2: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Belongs to the nuclear hormone receptor family. NR4 subfamily.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 2q22-q23
Cellular Component: nucleoplasm; nucleus
Molecular Function: beta-catenin binding; DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; retinoid X receptor binding
Biological Process: cellular response to extracellular stimulus; fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; neuron migration; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin
Disease: Parkinson Disease, Late-onset
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Product Notes
The Nurr1 nr4a2 (Catalog #AAA555222) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Nurr1, Affinity Purified Antibody, Rabbit reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Nurr1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the Nurr1 nr4a2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nurr1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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