Western Blot (WB)
(Western Blot analysis of NR2C2 expression in transfected 293T cell line by NR2C2 polyclonal antibody. Lane 1: NR2C2 transfected lysate (57.5kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human NR2C2 Polyclonal Antibody | anti-NR2C2 antibody
NR2C2 (Nuclear Receptor Subfamily 2 Group C Member 2, Orphan Nuclear Receptor TAK1, Orphan Nuclear Receptor TR4, Testicular Receptor 4, TAK1, TR4) APC
Gene Names
NR2C2; TR4; TAK1
Reactivity
Human
Applications
Western Blot
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
NR2C2; Polyclonal Antibody; NR2C2 (Nuclear Receptor Subfamily 2 Group C Member 2; Orphan Nuclear Receptor TAK1; Orphan Nuclear Receptor TR4; Testicular Receptor 4; TAK1; TR4) APC; anti-NR2C2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human NR2C2.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Sequence Length
3319
Applicable Applications for anti-NR2C2 antibody
Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Full length human NR2C2, aa1-530 (AAH51670.1).
Immunogen Sequence
MTSPSPRIQIISTDSAVASPQRIQGSEPASGPLSVFTSLNKEKIVTDQQTGQKIQIVTAVDASGSPKQQFTLTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSKRKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPGKICGGDA
Conjugate
APC
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(Western Blot analysis of NR2C2 expression in transfected 293T cell line by NR2C2 polyclonal antibody. Lane 1: NR2C2 transfected lysate (57.5kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of NR2C2 expression in transfected 293T cell line by NR2C2 polyclonal antibody. Lane 1: NR2C2 transfected lysate (57.5kD). Lane 2: Non-transfected lysate.)
Related Product Information for anti-NR2C2 antibody
TR4 is a NR2 Hepatocyte NF4-Like nuclear hormone receptor and transcription factor related to the orphan receptors TR2, COUP-TFI, and ARP-1. TR4 has been shown to affect the proliferation and maturation of brain structures, neurogenesis, the regulation of myeloid progenitor cell proliferation and development, and retinoid-mediated signaling pathways. TR4 binds to target DNA as a homodimer or a monomer, and has been shown to affect transcription of ciliary neurotrophic factor receptor (CNTFR alpha), luteinizing hormone receptor, and human steroid 21-hydroxylase genes. During development, the expression of TR4 in human and rat brain correlates with the progression of neuronal maturation. TR4 becomes progressively restricted to the hypothalamus and cerebellum in older embryos and adults. Recently, it has been shown that TR4 can suppress estrogen receptor function via direct protein-protein interaction. Three rat and two human TR4 mRNA splice variants have been documented.
Product Categories/Family for anti-NR2C2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Homo sapiens nuclear receptor subfamily 2, group C, member 2, mRNA
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group C member 2
NCBI Official Symbol
NR2C2
NCBI Official Synonym Symbols
TR4; TAK1
NCBI Protein Information
nuclear receptor subfamily 2 group C member 2
Protein Family
NCBI Description
This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Research Articles on NR2C2
Similar Products
Product Notes
The NR2C2 (Catalog #AAA6387437) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NR2C2 (Nuclear Receptor Subfamily 2 Group C Member 2, Orphan Nuclear Receptor TAK1, Orphan Nuclear Receptor TR4, Testicular Receptor 4, TAK1, TR4) APC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NR2C2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the NR2C2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NR2C2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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