Rabbit anti-Human NLRP13 Polyclonal Antibody | anti-NLRP13 antibody

Rabbit Polyclonal to Human NLRP13

Cat. Num. AAA246923

• Gene Names: NLRP13; NOD14; PAN13; NALP13; CLR19.7
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: NLRP13; Polyclonal Antibody; Rabbit Polyclonal to Human NLRP13; Anti-NLRP13 Antibody (N-Terminus) IHC-plus; NALP13; PAN13; CLR19.7; NOD14; Human NLRP13; anti-NLRP13 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human NALP13
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1043

• Applicable Applications for anti-NLRP13 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: NALP13 antibody can be used for detection of NALP13 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 19 amino acid peptide near the amino terminus of human NALP13.
• Immunogen Type: Synthetic peptide
• Immunogen: NLRP13 antibody was raised against a 19 amino acid peptide near the amino terminus of human NALP13.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-NLRP13 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-NLRP13 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of NALP13 in K562 cells with NALP13 antibody at 20 ug/ml.)

Immunocytochemistry (ICC)

(Immunocytochemistry of NALP13 in K562 cells with NALP13 antibody at 2.5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 110624785
• NCBI GeneID: 126204
• NCBI Accession #: NP_789780.2
• NCBI GenBank Nucleotide #: NM_176810.2
• UniProt Accession #: Q86W25; Q7RTR5
• Molecular Weight: 118,884 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 13
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 13
• NCBI Official Symbol: NLRP13
• NCBI Official Synonym Symbols: NOD14; PAN13; NALP13; CLR19.7
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 13; NACHT, LRR and PYD containing protein 13; NACHT, leucine rich repeat and PYD containing 13; nucleotide-binding oligomerization domain protein 14; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 13
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP13
• UniProt Synonym Gene Names: NALP13; NOD14
• UniProt Entry Name: NAL13_HUMAN

NCBI Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP13, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP13: Involved in inflammation (Potential). Belongs to the NLRP family.

Chromosomal Location of Human Ortholog: 19q13.43

Molecular Function: ATP binding