Western Blot (WB)
(WB Suggested Anti-Nkx3-2 Antibody Titration: 0.2-1 ug/mlPositive Control: Mouse Liver)
Rabbit Nkx3-2 Polyclonal Antibody | anti-NKX3-2 antibody
Nkx3-2 antibody - middle region
Western Blot (WB)
(WB Suggested Anti-Nkx3-2 Antibody Titration: 0.2-1 ug/mlPositive Control: Mouse Liver)
Western Blot (WB)
(WB Suggested Anti-Nkx3-2 Antibody Titration: 0.2-1 ug/mlPositive Control: Mouse Liver)
Target Description: The function of this protein remains unknown.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
Uniprot Description
NKX3-2: Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Defects in NKX3-2 are the cause of spondylo- megaepiphyseal-metaphyseal dysplasia (SMMD). It is a skeletal dysplasia characterized by disproportionate short stature with a short and stiff neck and trunk, relatively long limbs that may show flexion contractures of the distal joints, delayed and impaired ossification of the vertebral bodies, the presence of large epiphysea ossification centers and wide growth plates in the long tubular bones and numerous pseudoepiphyses of the short tubular bones in hands and feet. Belongs to the NK-3 homeobox family.
Protein type: Cell development/differentiation; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: nucleus
Biological Process: transcription from RNA polymerase II promoter; spleen development; organ formation; skeletal morphogenesis; embryonic skeletal development; negative regulation of chondrocyte differentiation; pancreas development; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; determination of left/right symmetry; skeletal development; negative regulation of apoptosis
Disease: Spondylo-megaepiphyseal-metaphyseal Dysplasia
Research Articles on NKX3-2
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Product Notes
The NKX3-2 nkx3-2 (Catalog #AAA3203321) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Nkx3-2 antibody - middle region reacts with Cow, Dog, Guinea Pig, Mouse, Rabbit, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Nkx3-2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NKX3-2 nkx3-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: SASVSGDHSP RGEDDSVSPG GARVPGLRGA AGSGASGGQA GGVEEEEEPA. It is sometimes possible for the material contained within the vial of "Nkx3-2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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