Rabbit MYT1L Polyclonal Antibody | anti-MYT1L antibody

MYT1L Antibody

Cat. Num. AAA153519

• Gene Names: MYT1L; NZF1; ZC2HC4B
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: MYT1L Antibody is affinity chromatography purified via peptide column.
• Synonyms: MYT1L; Polyclonal Antibody; MYT1L Antibody; NZF1; ZC2HC4B; KIAA1106; Myelin transcription factor 1-like protein; MyT1-L; myelin transcription factor 1-like; anti-MYT1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.
• Purity/Purification: MYT1L Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 1184

• Applicable Applications for anti-MYT1L antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: MYT1L antibody can be used for detection of MYT1L by Western blot at 1 - 2 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L.
• Buffer: MYT1L Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: MYT1L antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of MYT1L in mouse brain tissue lysate with MYT1L antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunofluorescence (IF)

(Immunofluorescence of MYT1L in human brain with MYT1L antibody at 20 μg/mL.)

Related Product Information for anti-MYT1L antibody

MYT1L Antibody: The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.

NCBI and Uniprot Product Information

• NCBI GI #: 60498973
• NCBI GeneID: 23040
• NCBI Accession #: NP_055840
• NCBI GenBank Nucleotide #: NM_015025.3
• UniProt Accession #: Q9UL68; Q6IQ17; Q9UPP6; A7E2C7; B2RP54
• Molecular Weight: 130 kDa
• NCBI Official Full Name: myelin transcription factor 1-like protein isoform 2
• NCBI Official Synonym Full Names: myelin transcription factor 1-like
• NCBI Official Symbol: MYT1L
• NCBI Official Synonym Symbols: NZF1; ZC2HC4B
• NCBI Protein Information: myelin transcription factor 1-like protein; myT1-L; neural zinc finger transcription factor 1
• UniProt Protein Name: Myelin transcription factor 1-like protein
• Protein Family: Myelin transcription factor 1-like protein
• UniProt Gene Name: MYT1L
• UniProt Synonym Gene Names: KIAA1106; MyT1-L; MyT1L
• UniProt Entry Name: MYT1L_HUMAN

Uniprot Description

MYT1L: May function as a panneural transcription factor associated with neuronal differentiation. May play a role in the development of neurons and oligodendrogalia in the CNS. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 2p25.3

Cellular Component: nucleus

Molecular Function: DNA binding; zinc ion binding; transcription factor activity

Biological Process: nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cell differentiation

Disease: Mental Retardation, Autosomal Dominant 39