Western Blot (WB)
(The anti-NIK Pab is used in Western blot to detect NIK in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2).)
Rabbit anti-Human, rat NIK Polyclonal Antibody | anti-MAP3K14 antibody
NIK Antibody (Center)
Western Blot (WB)
(The anti-NIK Pab is used in Western blot to detect NIK in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2).)
Western Blot (WB)
(The anti-NIK Pab is used in Western blot to detect NIK in 293 cell lysate (Lane 1) and rat testis tissue lysate (Lane 2).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Ninomiya-Tsuji, J., et al., Nature 398(6724):252-256 (1999).
Aronsson, F.C., et al., Hum. Genet. 103(3):340-345 (1998).
Lin, X., et al., Mol. Cell. Biol. 18(10):5899-5907 (1998).
Malinin, N.L., et al., Nature 385(6616):540-544 (1997).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
Uniprot Description
Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; Protein kinase, STE; Kinase, protein; STE group; STE-Unique family
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytosol
Molecular Function: MAP kinase kinase activity; NF-kappaB-inducing kinase activity; protein binding; MAP kinase kinase kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of MAPKK activity; activation of MAPK activity; T cell costimulation; MAPKKK cascade; immune response; protein amino acid phosphorylation
Research Articles on MAP3K14
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Product Notes
The MAP3K14 map3k14 (Catalog #AAA9201819) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 119-148. The NIK Antibody (Center) reacts with Human, rat and may cross-react with other species as described in the data sheet. AAA Biotech's NIK can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the MAP3K14 map3k14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NIK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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