Rabbit anti-Mouse NFYC Polyclonal Antibody | anti-NFYC antibody

NFYC Rabbit pAb

Cat. Num. AAA8547647

• Gene Names: NFYC; HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: NFYC; Polyclonal Antibody; NFYC Rabbit pAb; HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A; anti-NFYC antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 334

• Applicable Applications for anti-NFYC antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 86-335 of human NFYC (NP_055038.2).
• Cellular Localization: Nucleus
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-NFYC antibody

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

NCBI and Uniprot Product Information

• NCBI GI #: 217272829
• NCBI GeneID: 4802
• NCBI Accession #: NP_001136059.1
• NCBI GenBank Nucleotide #: NP_001136059.1
• UniProt Accession #: Q13952
• Molecular Weight: 50kDa
• NCBI Official Full Name: nuclear transcription factor Y subunit gamma isoform 3
• NCBI Official Synonym Full Names: nuclear transcription factor Y subunit gamma
• NCBI Official Symbol: NFYC
• NCBI Official Synonym Symbols: HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A
• NCBI Protein Information: nuclear transcription factor Y subunit gamma
• UniProt Protein Name: Nuclear transcription factor Y subunit gamma
• Protein Family: Nuclear transcription factor
• UniProt Gene Name: NFYC
• UniProt Synonym Gene Names: NF-YC
• UniProt Entry Name: NFYC_HUMAN

NCBI Description

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

NFYC: Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes. Belongs to the NFYC/HAP5 subunit family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: nucleoplasm; CCAAT-binding factor complex; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: regulation of transcription from RNA polymerase II promoter; protein folding; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cellular lipid metabolic process