Rabbit anti-Human NFATC3 Polyclonal Antibody | anti-NFATC3 antibody

anti-NFATC3 antibody

Cat. Num. AAA7611930

• Gene Names: NFATC3; NFAT4; NFATX
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Synonyms: NFATC3; Polyclonal Antibody; anti-NFATC3 antibody; NF AT4; NF ATc3; NFAT4; NFATX

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Form/Format: Liquid. PBS with 0.02% sodium azide and 50% glycerol pH7.3

• Applicable Applications for anti-NFATC3 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: WB: 1:200-1:2000; IHC: 1:50-1:200
• Immunogen: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
• Preparation and Storage: Store at -20 degree C for 12 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS7611930(NFATC3 antibody) at dilution of 1:100)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7611930(NFATC3 Antibody) at dilution of 1:1000)

Related Product Information for anti-NFATC3 antibody

Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2.

Product Categories/Family for anti-NFATC3 antibody

Immunology; Metabolism; Developmental biology

NCBI and Uniprot Product Information

• NCBI GI #: 4758804
• NCBI GeneID: 4775
• NCBI Accession #: NP_004546.1
• NCBI GenBank Nucleotide #: NM_004555.3
• UniProt Accession #: Q12968; O75211; Q14516; Q99840; Q99841; Q99842
• Molecular Weight: 115,594 Da
• NCBI Official Full Name: nuclear factor of activated T-cells, cytoplasmic 3 isoform 2
• NCBI Official Synonym Full Names: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
• NCBI Official Symbol: NFATC3
• NCBI Official Synonym Symbols: NFAT4; NFATX
• NCBI Protein Information: nuclear factor of activated T-cells, cytoplasmic 3; NF-ATc3; T cell transcription factor NFAT4; nuclear factor of activated T-cells c3 isoform IE-Xa
• UniProt Protein Name: Nuclear factor of activated T-cells, cytoplasmic 3
• Protein Family: Nuclear factor of activated T-cells
• UniProt Gene Name: NFATC3
• UniProt Synonym Gene Names: NFAT4; NF-ATc3; NFATc3; NF-AT4
• UniProt Entry Name: NFAC3_HUMAN

NCBI Description

The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]

Uniprot Description

NFAT4: a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: nucleoplasm; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; chromatin binding

Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; heart development; cellular respiration; muscle cell development; innate immune response; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response