Rabbit Neurotrypsin Polyclonal Antibody | anti-PRSS12 antibody

Neurotrypsin Antibody

Cat. Num. AAA9407832

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: Neurotrypsin; Polyclonal Antibody; Neurotrypsin Antibody; Motopsin; Protease serine 12; PRSS12; MRT1; BSSP3; anti-PRSS12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 875

• Applicable Applications for anti-PRSS12 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 23 amino acid peptide from near the amino terminus of human neurotrypsin.
• Target Name: Neurotrypsin
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of neurotrypsin in SK-N-SH cell lysate with neurotrypsin antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of Neurotrypsin in human brain tissue with Neurotrypsin antibody at 2.5 ug/mL.)

Related Product Information for anti-PRSS12 antibody

Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.

Product Categories/Family for anti-PRSS12 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 2661424
• UniProt Accession #: P56730; Q9UP16
• Molecular Weight: 97,067 Da
• NCBI Official Full Name: neurotrypsin
• UniProt Protein Name: Neurotrypsin
• Protein Family: Neurotrypsin
• UniProt Gene Name: PRSS12
• UniProt Entry Name: NETR_HUMAN

Uniprot Description

PRSS12: Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Belongs to the peptidase S1 family.

Protein type: Vesicle; Protease; Secreted, signal peptide; Secreted; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 4q28.1

Cellular Component: axon; dendrite; plasma membrane; extracellular region; terminal button; cytoplasmic vesicle

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; exocytosis; zymogen activation; proteolysis

Disease: Mental Retardation, Autosomal Recessive 1