Rabbit Neuropeptide Y Receptor, Type 1 Polyclonal Antibody | anti-NPY1R antibody

Neuropeptide Y Receptor, Type 1 (NPY1R, NPYR, NPYY1, NPY1-R)

Cat. Num. AAA624360

• Gene Names: NPY1R; NPYR
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Neuropeptide Y Receptor; Type 1; Polyclonal Antibody; Type 1 (NPY1R; NPYR; NPYY1; NPY1-R); Anti -Neuropeptide Y Receptor; anti-NPY1R antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human NPY1R. Species Crossreactivity: mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with sterile dH2O.

• Applicable Applications for anti-NPY1R antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1ug/ml; Immunohistochemistry (paraffin): 1-2ug/ml
• Immunogen: Synthetic peptide mapping at the C-terminal of human NPY1R, identical to the related rat and mouse sequence.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-NPY1R antibody

Neuropeptide Y Receptor Y1 (NPY1R) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiological activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system.. Two major subtypes of NPY receptor (Y1 and Y2) have been defined by pharmacological criteria. NPY1R and NPY2R encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis. NPY1R is required for central physiological and pharmacological NPY-induced analgesia and that its activation is both sufficient and required for the release of substance P and initiation of neurogenic inflammation.

Product Categories/Family for anti-NPY1R antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4505445
• NCBI GeneID: 4886
• NCBI Accession #: NP_000900.1
• NCBI GenBank Nucleotide #: NM_000909.5
• UniProt Accession #: P25929; B2R6H5; Q59G72
• Molecular Weight: 44,392 Da
• NCBI Official Full Name: neuropeptide Y receptor type 1
• NCBI Official Synonym Full Names: neuropeptide Y receptor Y1
• NCBI Official Symbol: NPY1R
• NCBI Official Synonym Symbols: NPYR
• NCBI Protein Information: neuropeptide Y receptor type 1; NPY1-R; OTTHUMP00000220111; OTTHUMP00000220115
• UniProt Protein Name: Neuropeptide Y receptor type 1
• Protein Family: Neuropeptide Y receptor
• UniProt Gene Name: NPY1R
• UniProt Synonym Gene Names: NPYR; NPYY1
• UniProt Entry Name: NPY1R_HUMAN

NCBI Description

Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (Herzog et al., 1992 [PubMed 1321422]).[supplied by OMIM]

Uniprot Description

NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q31.3-q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; regulation of multicellular organism growth; glucose metabolic process; locomotory behavior; feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain