Rabbit anti-Human, Mouse NPY1R Polyclonal Antibody | anti-NPY1R antibody

NPY1R antibody

Cat. Num. AAA9405621

• Gene Names: NPY1R; NPYR; NPY1-R
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: NPY1R; Polyclonal Antibody; NPY1R antibody; NPYR; NPY1-R; anti-NPY1R antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total NPY1R antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 384

• Applicable Applications for anti-NPY1R antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:500 - 1:2000; Immunohistochemistry: 1:25- 1:100
• Immunogen Type: Peptide
• Immunogen Description: A synthetic peptide of human NPY1R.
• Target Name: NPY1R
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of mouse fetal brain cell line, using NPY1R antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human gastric cancer tissue using NPY1R antibody.)

Related Product Information for anti-NPY1R antibody

Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle.

Product Categories/Family for anti-NPY1R antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4505445
• NCBI GeneID: 4886
• NCBI Accession #: NP_000900.1
• NCBI GenBank Nucleotide #: NM_000909.5
• UniProt Accession #: P25929; B2R6H5
• Molecular Weight: 44,392 Da
• NCBI Official Full Name: neuropeptide Y receptor type 1
• NCBI Official Synonym Full Names: neuropeptide Y receptor Y1
• NCBI Official Symbol: NPY1R
• NCBI Official Synonym Symbols: NPYR; NPY1-R
• NCBI Protein Information: neuropeptide Y receptor type 1
• UniProt Protein Name: Neuropeptide Y receptor type 1
• Protein Family: Neuropeptide Y receptor
• UniProt Gene Name: NPY1R
• UniProt Synonym Gene Names: NPYR; NPYY1; NPY1-R
• UniProt Entry Name: NPY1R_HUMAN

NCBI Description

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

Uniprot Description

NPY1R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.3-q32

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; pancreatic polypeptide receptor activity; neuropeptide Y receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; regulation of blood pressure; glucose metabolic process; regulation of multicellular organism growth; feeding behavior; locomotory behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain