Rabbit NETO1 Polyclonal Antibody | anti-NETO1 antibody

NETO1 Antibody

Cat. Num. AAA9405842

• Gene Names: NETO1; BCTL1; BTCL1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NETO1; Polyclonal Antibody; NETO1 Antibody; Neuropilin and tolloid-like 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; BCTL1; BTCL1; anti-NETO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: NETO1 antibody is predicted to not cross-react with other NETO protein family members.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 532

• Applicable Applications for anti-NETO1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen Type: Peptide
• Immunogen Description: Raised against an 18 amino acid peptide near the carboxy terminus of human NETO1.
• Target Name: NETO1
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NETO1 in human lung tissue lysate with NETO1 antibody at (A) 1 and (B) 2 ug/mL.)

Related Product Information for anti-NETO1 antibody

Neuropilin and tolloid-like protein 1 (NETO1) is involved in the development and/or maintenance of neuronal circuitry. It is a type I transmembrane protein that is expressed in the brain and retina. NETO1 contains one LDL-receptor class A domain and two CUB domains and is either membrane-bound or secreted. It has three alternatively spliced isoforms, the first two of which are retina-specific and the third of which is found in both retina and brain tissue. Furthermore, as an accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR), it regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.

Product Categories/Family for anti-NETO1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 23510396
• NCBI GeneID: 81832
• NCBI Accession #: NP_694821
• NCBI GenBank Nucleotide #: NM_153181.2
• Molecular Weight: 60,060 Da
• NCBI Official Synonym Full Names: neuropilin (NRP) and tolloid (TLL)-like 1
• NCBI Official Symbol: NETO1
• NCBI Official Synonym Symbols: BCTL1; BTCL1
• NCBI Protein Information: neuropilin and tolloid-like protein 1
• UniProt Protein Name: Neuropilin and tolloid-like protein 1
• Protein Family: Neuropilin and tolloid-like protein
• UniProt Gene Name: NETO1
• UniProt Synonym Gene Names: BTCL1
• UniProt Entry Name: NETO1_HUMAN

NCBI Description

This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Uniprot Description

NETO1: a transmembrane protein and component of the N-methyl-D-aspartate receptor (NMDAR) complex. Required to maintain the normal level of NMDAR subunits at synapses. The NMDAR complex is a major excitatory ligand-gated ion channel in the central nervous system and a major mediator of synaptic plasticity. Important in the development and/or maintenance of neuronal circuitry. Neto1-deficient mice have a dramatic decrease in the number of NMDA receptors at synapses, impairing learning and synaptic plasticity. Three isoforms of the human protein are produced by alternative splicing. Isoforms 1 and 2 are retina-specific whereas isoform 3 is found in retina as well as at lower levels in adult and fetal brain.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.2

Cellular Component: postsynaptic membrane; kainate selective glutamate receptor complex; postsynaptic density; extracellular region; excitatory synapse; cell junction

Molecular Function: ionotropic glutamate receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; visual learning; memory