Immunohistochemistry (IHC)
(Nestin [IHC638] on Melanoma)
Mouse anti-Human Nestin Monoclonal Antibody | anti-NES antibody
Nestin
Gene Names
NES; Nbla00170
Reactivity
Human
Synonyms
Nestin; Monoclonal Antibody; anti-NES antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Sequence Length
1621
Application Notes
The recommended working dilution range is 1:100-1:200
Positive Control
Tonsil
Immunohistochemistry (IHC)
(Nestin [IHC638] on Melanoma)
Immunohistochemistry (IHC)
(Nestin [IHC638] on Melanoma)
Related Product Information for anti-NES antibody
Nestin is a type IV intermediate filament protein that is expressed in dividing cells during early stages of Central Nervous System (CNS) and Peripheral Nervous System (PNS) development, as well as that of myogenic and other tissue types. Overexpression of nestin has been clinically linked to human gliomas, as well as tumors of the CNS such as astrocytoma, ependymoma, oligodendroglioma, glioblastoma, and primitive neuroectodermal tumors. Nestin expression has also been indicated in prostatic adenocarcinoma, pancreatic ductal carcinoma, thyroid carcinoma, and mesenchymal tumors such as gastrointestinal stromal tumor and dermatofibrosarcoma protuberans. Reports have suggested that nestin is significantly overexpressed in melanoma, and linked to more advanced stages of the disease.
References
1. Michalczyk K, et al. Histol Histopathol. 2005; 20:665-71.
2. Maho K, et al. J Dermatol. 2010; 37:505-11.
3. Toshiyuki I, et al. World J Gastroenterol. 2011; 17:409-18.
4. Brychtova S, et al. J Cutan Pathol. 2007; 34:370-5.
5. Kanoh M, et al. J Dermatol. 2010; 37:505-11.
6. Ishiwata T, et al. World J Gastroenterol. 2011; 17:409-18.
7. Li H, et al. Cancer Res. 2007; 67:501-10.
2. Maho K, et al. J Dermatol. 2010; 37:505-11.
3. Toshiyuki I, et al. World J Gastroenterol. 2011; 17:409-18.
4. Brychtova S, et al. J Cutan Pathol. 2007; 34:370-5.
5. Kanoh M, et al. J Dermatol. 2010; 37:505-11.
6. Ishiwata T, et al. World J Gastroenterol. 2011; 17:409-18.
7. Li H, et al. Cancer Res. 2007; 67:501-10.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
177,439 Da
NCBI Official Full Name
nestin
NCBI Official Synonym Full Names
nestin
NCBI Official Symbol
NES
NCBI Official Synonym Symbols
Nbla00170
NCBI Protein Information
nestin
UniProt Protein Name
Nestin
Protein Family
UniProt Gene Name
NES
NCBI Description
This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]
Uniprot Description
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells ().
Research Articles on NES
Similar Products
Product Notes
The NES nes (Catalog #AAA344072) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Nestin reacts with Human and may cross-react with other species as described in the data sheet. The recommended working dilution range is 1:100-1:200. Researchers should empirically determine the suitability of the NES nes for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nestin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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