Rabbit anti-Human Nectin 2 Polyclonal Antibody | anti-NECTIN2 antibody

Nectin 2 (Nectin-2, AI325026, AI987993, CD112, Herpes Virus Entry Mediator B, Herpes virus Entry Mediator B, HveB, Murine Herpes Virus Entry Protein B, mHveB, Mph, Poliovirus Receptor Homolog, Poliovirus Receptor-related Protein 2, PRR2, Pvr, Pvrl2, Pvs)

Cat. Num. AAA6386789

• Gene Names: NECTIN2; HVEB; PRR2; CD112; PVRL2; PVRR2
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Nectin 2; Polyclonal Antibody; Nectin 2 (Nectin-2; AI325026; AI987993; CD112; Herpes Virus Entry Mediator B; Herpes virus Entry Mediator B; HveB; Murine Herpes Virus Entry Protein B; mHveB; Mph; Poliovirus Receptor Homolog; Poliovirus Receptor-related Protein 2; PRR2; Pvr; Pvrl2; Pvs); anti-NECTIN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PVRL2.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-NECTIN2 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PVRL2, aa1-479 (NP_002847.1).
• Immunogen Sequence: MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDMESQLDGSLISRRAVYV
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PVRL2 rabbit polyclonal antibody. Western Blot analysis of PVRL2 expression in human pancreas.)

Western Blot (WB)

(Western Blot analysis of PVRL2 expression in transfected 293T cell line by PVRL2 polyclonal antibody. Lane 1: PVRL2 transfected lysate (51.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-NECTIN2 antibody

Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of nectin 1, nectin 2 and nectin 3. Nectin 2 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice.

Product Categories/Family for anti-NECTIN2 antibody

Antibodies; Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 5360210
• NCBI GeneID: 5819
• NCBI Accession #: NP_002847.1
• NCBI GenBank Nucleotide #: NM_002856.2
• UniProt Accession #: Q92692; O75455; Q6IBI6; Q96J29; A8K5L5
• Molecular Weight: 51,359 Da
• NCBI Official Full Name: nectin-2 isoform alpha
• NCBI Official Synonym Full Names: nectin cell adhesion molecule 2
• NCBI Official Symbol: NECTIN2
• NCBI Official Synonym Symbols: HVEB; PRR2; CD112; PVRL2; PVRR2
• NCBI Protein Information: nectin-2
• UniProt Protein Name: Nectin-2
• Protein Family: Nectin
• UniProt Gene Name: NECTIN2
• UniProt Synonym Gene Names: Herpesvirus entry mediator B; HveB

NCBI Description

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).