Western Blot (WB)
(Western blot analysis of RAW264.7 cell Rat brain tissue and Mouse brain tissue lysates using NDRG4 Polyclonal Antibody at dilution of 1:650)
Rabbit NDRG4 Polyclonal Antibody | anti-NDRG4 antibody
NDRG4 Polyclonal Antibody
IHC: 1:50-1:100
ELISA: 1:5000-1:10000
Western Blot (WB)
(Western blot analysis of RAW264.7 cell Rat brain tissue and Mouse brain tissue lysates using NDRG4 Polyclonal Antibody at dilution of 1:650)
Western Blot (WB)
(Western blot analysis of RAW264.7 cell Rat brain tissue and Mouse brain tissue lysates using NDRG4 Polyclonal Antibody at dilution of 1:650)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using NDRG4 Polyclonal Antibody at dilution of 1:45(×200))
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using NDRG4 Polyclonal Antibody at dilution of 1:45(×200))
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]
Uniprot Description
NDRG4: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Expressed predominantly in brain and heart. In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. Belongs to the NDRG family. 6 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: endoplasmic reticulum membrane; mitochondrion; basolateral plasma membrane; cytoplasm; cytosol
Biological Process: negative regulation of smooth muscle cell proliferation; response to stress; embryonic heart tube development; cardiac muscle cell proliferation; heart looping; negative regulation of smooth muscle cell migration; cell growth; cell differentiation
Research Articles on NDRG4
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Product Notes
The NDRG4 ndrg4 (Catalog #AAA2563187) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NDRG4 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NDRG4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA). WB: 1:500-1:2000 IHC: 1:50-1:100 ELISA: 1:5000-1:10000. Researchers should empirically determine the suitability of the NDRG4 ndrg4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NDRG4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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