Rabbit anti-Rat NCX1 Polyclonal Antibody | anti-SLC8A1 antibody
NCX1 (Sodium Calcium Exchanger)
Purified over the peptide-Sepharose column
Purified over the peptide-Sepharose column
Dilution: Western Blot: 1-10ug/ml using ECL.
ELISA: 0.5-1ug/ml. Control peptide N0560-20B can be used to coat ELISA plates at 1ug/ml.
Immunohistochemistry (PFFE): 5-20ug/ml. 4% paraformaldehyde.
NCBI and Uniprot Product Information
NCBI Description
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]
Uniprot Description
NCX1: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family
Chromosomal Location of Human Ortholog: 2p22.1
Cellular Component: integral to plasma membrane; basolateral plasma membrane; T-tubule; plasma membrane; Z disc; sarcolemma
Molecular Function: calmodulin binding; metal ion binding; cytoskeletal protein binding; ankyrin binding; calcium:sodium antiporter activity
Biological Process: heart morphogenesis; embryonic placenta development; cellular sodium ion homeostasis; regulation of heart rate; vascular smooth muscle contraction; post-embryonic development; calcium ion homeostasis; cardiac muscle cell development; muscle contraction; reduction of cytosolic calcium ion concentration; embryonic heart tube development; ion transport; blood coagulation; muscle fiber development; transmembrane transport; regulation of the force of heart contraction; cardiac muscle contraction
Research Articles on SLC8A1
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Product Notes
The SLC8A1 ncx1 (Catalog #AAA617147) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NCX1 (Sodium Calcium Exchanger) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NCX1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA, Western Blot and Immunohistochemistry. Dilution: Western Blot: 1-10ug/ml using ECL. ELISA: 0.5-1ug/ml. Control peptide N0560-20B can be used to coat ELISA plates at 1ug/ml. Immunohistochemistry (PFFE): 5-20ug/ml. 4% paraformaldehyde. Researchers should empirically determine the suitability of the SLC8A1 ncx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NCX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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