Goat MYRIP Polyclonal Antibody | anti-MYRIP antibody

Goat Polyclonal to Human MYRIP

Cat. Num. AAA242922

• Gene Names: MYRIP; SLAC2C; SLAC2-C
• Reactivity: Gibbon, Gorilla, Human, Monkey; Predicted Reactivity: Mouse, Rat, Bat, Dog, Horse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: MYRIP; Polyclonal Antibody; Goat Polyclonal to Human MYRIP; Anti-MYRIP Antibody (C-Terminus) IHC-plus; Rab effector MyRIP; SLAC2-C; SLAC2C; Exophilin-8; Human MYRIP; anti-MYRIP antibody

• Host: Goat
• Reactivity: Gibbon, Gorilla, Human, Monkey; Predicted Reactivity: Mouse, Rat, Bat, Dog, Horse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human MYRIP.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 859

• Applicable Applications for anti-MYRIP antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:64000), IHC-P (3.75 ug/ml), WB (1:64000, 0.1 - 0.3 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-KDLMEPALESAVMY from the C-terminus of human MYRIP (NP_056275.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Dog, Bat, Horse (93%); Elephant, Pig, Chicken (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: MYRIP antibody was raised against synthetic peptide C-KDLMEPALESAVMY from the C-terminus of human MYRIP (NP_056275.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Dog, Bat, Horse (93%); Elephant, Pig, Chicken (86%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-MYRIP antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-MYRIP antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-MYRIP antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Western Blot (WB)

(Antibody staining (0.1 ug/ml) of Human Duodenum lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.)

NCBI and Uniprot Product Information

• NCBI GI #: 59853352
• NCBI GeneID: 25924
• NCBI Accession #: NP_056275.2
• NCBI GenBank Nucleotide #: NM_015460.3
• UniProt Accession #: Q8NFW9; Q32M41; Q32M42; Q569F7; Q8IUF5; Q9Y3V4; B3KWM3; B3KWW4; B7Z2H1; B7Z9V3; G3XAI8
• Molecular Weight: 83,948 Da
• NCBI Official Full Name: rab effector MyRIP isoform a
• NCBI Official Synonym Full Names: myosin VIIA and Rab interacting protein
• NCBI Official Symbol: MYRIP
• NCBI Official Synonym Symbols: SLAC2C; SLAC2-C
• NCBI Protein Information: rab effector MyRIP; exophilin-8; Slp homologue lacking C2 domains; slp homolog lacking C2 domains c; myosin-VIIa- and Rab-interacting protein; synaptotagmin-like protein lacking C2 domains C; synaptotagmin-like protein homologue lacking C2 domains-c
• UniProt Protein Name: Rab effector MyRIP
• Protein Family: Rab effector
• UniProt Gene Name: MYRIP
• UniProt Synonym Gene Names: SLAC2C; SlaC2-c; Slp homolog lacking C2 domains c
• UniProt Entry Name: MYRIP_HUMAN

Uniprot Description

MYRIP: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3p22.1

Cellular Component: transport vesicle; photoreceptor outer segment; perinuclear region of cytoplasm; exocyst; melanosome; synapse; actin cytoskeleton

Molecular Function: protein binding; zinc ion binding; protein kinase A binding; actin binding; Rab GTPase binding

Biological Process: intracellular protein transport; positive regulation of insulin secretion