Rabbit anti-Human MYBPC3 Polyclonal Antibody | anti-MYBPC3 antibody

MYBPC3 Antibody

Cat. Num. AAA9608530

• Gene Names: MYBPC3; FHC; CMH4; CMD1MM; LVNC10; MYBP-C
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: MYBPC3; Polyclonal Antibody; MYBPC3 Antibody; C protein cardiac muscle isoform; C-protein; cardiac muscle isoform; Cardiac MyBP C; Cardiac MyBP-C; cardiac-type; myosin binding protein C cardiac; Myosin binding protein C cardiac type; Myosin-binding protein C; MYPC3_HUMAN; anti-MYBPC3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: MYBPC3 antibody detects endogenous levels of total MYBPC3
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1274

• Applicable Applications for anti-MYBPC3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-3000
• Immunogen: A synthesized peptide derived from human MYBPC3
• Predicted Cross Reactivity: Pig, Bovine, Rabbit, Dog
• Similarity: Pig (89%), Bovine (89%), Rabbit (89%), Dog (89%)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of MYBPC3 using Jurkat whole cell lysates)

Related Product Information for anti-MYBPC3 antibody

Function: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
Post-translational Modifications: Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction (By similarity). Polyubiquitinated.
Similarity: Belongs to the immunoglobulin superfamily. MyBP family.

NCBI and Uniprot Product Information

• NCBI GI #: 148596957
• NCBI GeneID: 4607
• NCBI Accession #: NP_000247.2
• NCBI GenBank Nucleotide #: NM_000256.3
• UniProt Accession #: Q14896; Q16410; Q6R2F7; Q9UE27; Q9UM53; A5PL00
• Molecular Weight: Observed: 150 kDa; Predicted: 141 kDa
• NCBI Official Full Name: myosin-binding protein C, cardiac-type
• NCBI Official Synonym Full Names: myosin binding protein C, cardiac
• NCBI Official Symbol: MYBPC3
• NCBI Official Synonym Symbols: FHC; CMH4; CMD1MM; LVNC10; MYBP-C
• NCBI Protein Information: myosin-binding protein C, cardiac-type
• UniProt Protein Name: Myosin-binding protein C, cardiac-type
• Protein Family: Myosin-binding protein
• UniProt Gene Name: MYBPC3
• UniProt Synonym Gene Names: Cardiac MyBP-C

NCBI Description

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.