Rabbit anti-Human, Mouse MYBPC3 Polyclonal Antibody | anti-MYBPC3 antibody

MYBPC3 Antibody

Cat. Num. AAA7050079

• Gene Names: MYBPC3; FHC; CMH4; CMD1MM; LVNC10; MYBP-C
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: MYBPC3; Polyclonal Antibody; MYBPC3 Antibody; Myosin-binding protein C; cardiac-typeCardiac MyBP-C; C-protein; cardiac muscle isoform; anti-MYBPC3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 1274

• Applicable Applications for anti-MYBPC3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1: 500-1: 5000
• Immunogen: Recombinant Human Myosin-binding protein C, cardiac-type protein (1-328AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugation: Non-conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50114 / sc-50115 / sc-67353 / sc-67354
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in:Mouse heart tissueAll lanes: MYBPC3 antibody at 2.5ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 141 kDaObserved band size: 141 kDa)

Related Product Information for anti-MYBPC3 antibody

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

NCBI and Uniprot Product Information

• NCBI GI #: 148596957
• NCBI GeneID: 4607
• NCBI Accession #: NP_000247.2
• NCBI GenBank Nucleotide #: NM_000256.3
• UniProt Accession #: Q14896; Q16410; Q6R2F7; Q9UE27; Q9UM53; A5PL00
• Molecular Weight: 140,703 Da
• NCBI Official Full Name: myosin-binding protein C, cardiac-type
• NCBI Official Synonym Full Names: myosin binding protein C, cardiac
• NCBI Official Symbol: MYBPC3
• NCBI Official Synonym Symbols: FHC; CMH4; CMD1MM; LVNC10; MYBP-C
• NCBI Protein Information: myosin-binding protein C, cardiac-type
• UniProt Protein Name: Myosin-binding protein C, cardiac-type
• Protein Family: Myosin-binding protein
• UniProt Gene Name: MYBPC3
• UniProt Synonym Gene Names: Cardiac MyBP-C
• UniProt Entry Name: MYPC3_HUMAN

NCBI Description

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Description

MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.

Protein type: Myosin-binding

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: A band; cytosol; sarcomere; striated muscle thick filament

Molecular Function: ATPase activator activity; identical protein binding; myosin binding; myosin heavy chain binding; protein binding; structural constituent of muscle

Biological Process: cardiac muscle contraction; heart morphogenesis; muscle filament sliding; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Familial Hypertrophic, 4; Left Ventricular Noncompaction 10