Western Blot (WB)
(Western blot analysis of lysate from A431 cell line, using MUL1 Antibody (Center). MBS9210670 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.)
Rabbit MUL1 Polyclonal Antibody | anti-MUL1 antibody
MUL1 Antibody (Center)
Western Blot (WB)
(Western blot analysis of lysate from A431 cell line, using MUL1 Antibody (Center). MBS9210670 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.)
Western Blot (WB)
(Western blot analysis of lysate from A431 cell line, using MUL1 Antibody (Center). MBS9210670 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 35ug.)
Matsuda A.,et al.Oncogene 22:3307-3318(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Gregory S.G.,et al.Nature 441:315-321(2006).
NCBI and Uniprot Product Information
Uniprot Description
MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein type: Membrane protein, multi-pass; Ligase; Membrane protein, integral; Mitochondrial; Ubiquitin ligase; EC 6.3.2.-; Apoptosis; EC 6.3.2.19; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; peroxisome; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; signal transducer activity; protein binding; zinc ion binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; SUMO ligase activity; ligase activity
Biological Process: caspase activation; mitochondrial fission; positive regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of protein kinase B signaling cascade; protein stabilization; protein ubiquitination; negative regulation of defense response to virus by host; mitochondrion localization; activation of JNK activity; positive regulation of protein sumoylation; protein sumoylation; negative regulation of innate immune response; negative regulation of cell growth
Research Articles on MUL1
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Product Notes
The MUL1 mul1 (Catalog #AAA9210670) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MUL1 Antibody (Center) reacts with Human (Predicted Reactivity: Monkey, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's MUL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MUL1 mul1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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