Western Blot (WB)
(The anti-MST2 Pab is used in Western blot to detect MST2 in Jurkat cell lysate (lane 1) and mouse ovary tissue lysate (lane 2).)
Rabbit MST2 Polyclonal Antibody | anti-STK3 antibody
MST2 Antibody (C-term)
Western Blot (WB)
(The anti-MST2 Pab is used in Western blot to detect MST2 in Jurkat cell lysate (lane 1) and mouse ovary tissue lysate (lane 2).)
Western Blot (WB)
(The anti-MST2 Pab is used in Western blot to detect MST2 in Jurkat cell lysate (lane 1) and mouse ovary tissue lysate (lane 2).)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Taylor, L.K., et al., Proc. Natl. Acad. Sci. U.S.A. 93(19):10099-10104 (1996).
Schultz, S.J., et al., Cell Growth Differ. 4(10):821-830 (1993).
Creasy, C.L., et al., Gene 167 (1-2), 303-306 (1995).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Description
MST2: a protein kinase of the STE20 family. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Following cleavage by caspase-3, undergoes irreversible autophosphorylation. Full-length is mainly unphosphorylated in the rat thymus and cultured cells, whereas caspase-3-cleaved MST2 in apoptotic cells is highly phosphorylated.
Protein type: Protein kinase, Ser/Thr (non-receptor); Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; MST subfamily
Chromosomal Location of Human Ortholog: 8q22.2
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: protein dimerization activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity
Biological Process: central nervous system development; protein stabilization; positive regulation of protein binding; positive regulation of apoptosis; apoptosis; positive regulation of JNK cascade; negative regulation of organ growth; signal transduction; protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; negative regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; neural tube formation
Research Articles on STK3
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Product Notes
The STK3 stk3 (Catalog #AAA9205141) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 396-425. The MST2 Antibody (C-term) reacts with Human, mouse, rat, monkey and may cross-react with other species as described in the data sheet. AAA Biotech's MST2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the STK3 stk3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MST2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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