Rabbit anti-Human HERPUD1 Polyclonal Antibody | anti-HERPUD1 antibody

HERPUD1 (HERP, KIAA0025, MIF1, Homocysteine-responsive Endoplasmic Reticulum-resident Ubiquitin-like Domain Member 1 Protein, Methyl Methanesulfonate (MMF)-inducible Fragment Protein 1) (HRP)

Cat. Num. AAA6380983

• Gene Names: HERPUD1; SUP; HERP; Mif1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HERPUD1; Polyclonal Antibody; HERPUD1 (HERP; KIAA0025; MIF1; Homocysteine-responsive Endoplasmic Reticulum-resident Ubiquitin-like Domain Member 1 Protein; Methyl Methanesulfonate (MMF)-inducible Fragment Protein 1) (HRP); anti-HERPUD1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human HERPUD1.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 2198

• Applicable Applications for anti-HERPUD1 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human HERPUD1, aa1-391 (NP_055500.1).
• Immunogen Sequence: MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of HERPUD1 expression in transfected 293T cell line by HERPUD1 polyclonal antibody. Lane 1: HERPUD1 transfected lysate (43.7kD). Lane 2: Non-transfected lysate. )

Related Product Information for anti-HERPUD1 antibody

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq].

Product Categories/Family for anti-HERPUD1 antibody

Antibodies; Ubiquitin

NCBI and Uniprot Product Information

• NCBI GI #: 58530855
• NCBI GeneID: 9709
• NCBI Accession #: NM_014685.2
• NCBI GenBank Nucleotide #: NM_014685.2
• UniProt Accession #: Q15011
• NCBI Official Full Name: Homo sapiens homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: homocysteine inducible ER protein with ubiquitin like domain 1
• NCBI Official Symbol: HERPUD1
• NCBI Official Synonym Symbols: SUP; HERP; Mif1
• NCBI Protein Information: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
• UniProt Protein Name: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
• Protein Family: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
• UniProt Gene Name: HERPUD1
• UniProt Synonym Gene Names: HERP; KIAA0025; MIF1
• UniProt Entry Name: HERP1_HUMAN

NCBI Description

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]

Uniprot Description

HERPUD1: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane

Molecular Function: protein binding

Biological Process: endoplasmic reticulum calcium ion homeostasis; response to unfolded protein; retrograde protein transport, ER to cytosol