Rabbit anti-Human MPZL2 Polyclonal Antibody | anti-MPZL2 antibody

MPZL2, ID (MPZL2, EVA, EVA1, Myelin protein zero-like protein 2, Epithelial V-like antigen 1) (MaxLight 490)

Cat. Num. AAA6321994

• Gene Names: MPZL2; EVA; EVA1
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: MPZL2; Polyclonal Antibody; ID (MPZL2; EVA; EVA1; Myelin protein zero-like protein 2; Epithelial V-like antigen 1) (MaxLight 490); Epithelial V-like antigen 1; anti-MPZL2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human MPZL2.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-MPZL2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:1000; Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 67-94 in the central region of human MPZL2, UniProt Accession #NP_005788.1; O60487.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in NCI-H460 cell line lysates (35ug/lane) usingMBS6004335. This demonstrates that MBS6004335 detected the MPZL2 protein (arrow).)

Product Categories/Family for anti-MPZL2 antibody

Antibodies; Myelin

References

1. Kim, H., et al. Pharmacogenomics 10(2):171-179(2009). 2. Lamesch, P., et al. Genomics 89(3):307-315(2007). Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003). 3. Guttinger, M., et al. J. Cell Biol. 141(4):1061-1071(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 5032247
• NCBI GeneID: 10205
• NCBI Accession #: NP_005788.1
• NCBI GenBank Nucleotide #: NM_005797.3
• UniProt Accession #: O60487; A8K2R1
• Molecular Weight: 24,484 Da
• NCBI Official Full Name: myelin protein zero-like protein 2
• NCBI Official Synonym Full Names: myelin protein zero like 2
• NCBI Official Symbol: MPZL2
• NCBI Official Synonym Symbols: EVA; EVA1
• NCBI Protein Information: myelin protein zero-like protein 2
• UniProt Protein Name: Myelin protein zero-like protein 2
• Protein Family: Myelin protein zero-like protein
• UniProt Gene Name: MPZL2
• UniProt Synonym Gene Names: EVA; EVA1

NCBI Description

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Mediates homophilic cell-cell adhesion.