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BMP Binding Endothelial Regulator Recombinant Protein | BMPER recombinant protein
Recombinant BMP Binding Endothelial Regulator (BMPER)
Source: Prokaryotic expression
S SFLTGSVAKCENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGACCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCKNPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVREVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGASFVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDI
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
SDS-Page
SDS-Page
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted protein that interacts with, and inhibits bone morphogenetic protein (BMP) function. It has been shown to inhibit BMP2- and BMP4-dependent osteoblast differentiation and BMP-dependent differentiation of the chondrogenic cells. Mutations in this gene are associated with a lethal skeletal disorder, diaphanospondylodysostosis. [provided by RefSeq, Dec 2011]
Uniprot Description
BMPER: Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes. Defects in BMPER are the cause of diaphanospondylodysostosis (DSD). A rare, recessively inherited, perinatal lethal skeletal disorder. The primary skeletal characteristics of the phenotype include a small chest, abnormal vertebral segmentation, and posterior rib gaps containing incompletely differentiated mesenchymal tissue. Consistent craniofacial features include ocular hypertelorism, epicanthal folds, a depressed nasal bridge with a short nose, and low-set ears. The most commonly described extraskeletal finding is nephroblastomatosis with cystic kidneys, but other visceral findings have been described in some cases.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: extracellular space
Biological Process: endothelial cell differentiation; blood vessel endothelial cell proliferation during sprouting angiogenesis; ureteric bud development; inner ear development; negative regulation of BMP signaling pathway; endothelial cell activation
Disease: Diaphanospondylodysostosis
Research Articles on BMPER
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Product Notes
The BMPER bmper (Catalog #AAA2031541) is a Recombinant Protein produced from Host: E Coli Source: Prokaryotic expression and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's BMP Binding Endothelial Regulator can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the BMPER bmper for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.S SFLTGSVAKC ENEGEVLQIP FITDNPCIMC VCLNKEVTCK REKCPVLSRD CALAIKQRGA CCERCKGCTH EGRTYNSSFK WQTPAEPCVL RQCQEGVVTE SEVRCVVHCK NPAEHQGACC PTCPGCVFEG VQYREGEEFQ PEGNKCITCS CVGGRTQCVR EVCPILSCPQ HLSHTPSGQC CPKCLGQRKV FDLPFGSCLF RSDVYDNGAS FVYDNCTVCT CKDSTMVCKK KCSHPGVCNS DEDACCEDCL LRVPPEDI. It is sometimes possible for the material contained within the vial of "BMP Binding Endothelial Regulator, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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