Rabbit anti-Mouse MOSC2 Polyclonal Antibody | anti-MARC2 antibody

MOSC2, CT (MARC2, MOSC2, MOSC domain-containing protein 2, mitochondrial, Mitochondrial amidoxime reducing component 2, Moco sulfurase C-terminal domain-containing protein 2, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2)

Cat. Num. AAA649173

• Gene Names: MARC2; MOSC2; RP11-270A6.1
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: MOSC2; Polyclonal Antibody; CT (MARC2; MOSC domain-containing protein 2; mitochondrial; Mitochondrial amidoxime reducing component 2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2); Anti -MOSC2; anti-MARC2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-MARC2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: MOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-333 amino acids from the C-terminal region of human MOSC2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse spleen tissue lysates (35ug/lane), using MBS649173. This demonstrates that MBS649173 detected the MOSC2 protein (arrow).)

Related Product Information for anti-MARC2 antibody

Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.

Product Categories/Family for anti-MARC2 antibody

Antibodies; Abs to Mitochondrial Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 31542713
• NCBI GeneID: 54996
• NCBI Accession #: NP_060368.2
• NCBI GenBank Nucleotide #: NM_017898.3
• UniProt Accession #: Q969Z3; Q0JSK7; Q5VT67; Q5VXC7; Q7L317; Q9H066; Q9NWU0; B2D0R5; D3DTB3
• Molecular Weight: 38,023 Da
• NCBI Official Full Name: MOSC domain-containing protein 2, mitochondrial
• NCBI Official Synonym Full Names: mitochondrial amidoxime reducing component 2
• NCBI Official Symbol: MARC2
• NCBI Official Synonym Symbols: MOSC2; RP11-270A6.1
• NCBI Protein Information: MOSC domain-containing protein 2, mitochondrial; MOCO sulphurase C-terminal domain containing 2; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2
• UniProt Protein Name: MOSC domain-containing protein 2, mitochondrial
• UniProt Gene Name: MARC2
• UniProt Synonym Gene Names: MOSC2; mARC2
• UniProt Entry Name: MOSC2_HUMAN

Uniprot Description

Function: As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively. Ref.9

Cofactor: Molybdenum

Probable.

Subunit structure: Component of a complex composed of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3) and MOSC2

By similarity.

Subcellular location: Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome

By similarity.

Sequence similarities: Contains 1 MOSC domain.

Biophysicochemical propertiesKinetic parameters:KM=830 µM for benzamidoxime Ref.9KM=3 mM for NOHAKM=3.7 mM for NHAMVmax=307 nmol/min/mg enzyme toward benzamidoximeVmax=373 nmol/min/mg enzyme toward NOHAVmax=36.5 nmol/min/mg enzyme toward NHAM

Sequence caution: The sequence BAA91287.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAH70306.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH71880.1 differs from that shown. Reason: Erroneous gene model prediction.