Western Blot (WB)
(Anti-MAOA antibody, MBS175525, Western blottingAll lanes: Anti MAOA (MBS175525) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 60KDObserved bind size: 60KD)
Rabbit anti-Human Monoamine Oxidase A Polyclonal Antibody | anti-MAOA antibody
Anti-Monoamine Oxidase A antibody
Western Blot (WB)
(Anti-MAOA antibody, MBS175525, Western blottingAll lanes: Anti MAOA (MBS175525) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 60KDObserved bind size: 60KD)
Western Blot (WB)
(Anti-MAOA antibody, MBS175525, Western blottingAll lanes: Anti MAOA (MBS175525) at 0.5ug/mlWB: Human Placenta Tissue Lysate at 50ugPredicted bind size: 60KDObserved bind size: 60KD)
Immunohistochemistry (IHC)
(Anti-MAOA antibody, MBS175525, IHC(P)IHC(P): Human Placenta Tissue )
Immunohistochemistry (IHC)
(Anti-MAOA antibody, MBS175525, IHC(P)IHC(P): Human Placenta Tissue )
Background: MAOA(Monoamine oxidase A), also known as AMINE OXIDASE(FLAVIN-CONTAINING) A, is an enzyme that in humans is encoded by the MAO-A gene. MAOA is an isozyme of monoamine oxidase which is also mapped on Xp11.3. MAOA degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. Mutation in MAOA results in monoamine oxidase deficiency, or Brunner syndrome. In humans, there is a 30-base repeat sequence repeated in one of several different numbers of times in the promoter region of the gene coding for MAOA. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder. Inhibition of MAOA prevented apoptosis, and serum starvation of cortical brain cells from Maoa-deficient mice resulted in reduced apoptosis compared with wildtype mice.
NCBI and Uniprot Product Information
NCBI Description
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Uniprot Description
MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
Protein type: Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - tryptophan; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; EC 1.4.3.4
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane
Molecular Function: amine oxidase activity
Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; neurotransmitter secretion; xenobiotic metabolic process; neurotransmitter biosynthetic process
Disease: Brunner Syndrome
Research Articles on MAOA
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Product Notes
The MAOA maoa (Catalog #AAA175525) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Monoamine Oxidase An antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Monoamine Oxidase A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the MAOA maoa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Monoamine Oxidase A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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