Rabbit PAX9 Polyclonal Antibody | anti-PAX9 antibody

PAX9 Polyclonal Antibody

Cat. Num. AAA3013213

• Gene Names: PAX9; STHAG3
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: ProA affinity purified
• Synonyms: PAX9; Polyclonal Antibody; PAX9 Polyclonal Antibody; Paired box 9; Paired box gene 9; Paired box homeotic gene 9; Paired box protein 9; Paired box protein Pax 9; Paired box protein Pax-9; Paired box protein Pax9; Paired domain gene 9; PAX 9; STHAG3; anti-PAX9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PAX9 polyclonal antibody detects endogenous levels of PAX9 protein.
• Purity/Purification: ProA affinity purified
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 331

• Applicable Applications for anti-PAX9 antibody: Western Blot (WB)
• Application Notes: WB: 1:1,000-1:2,000
• Immunogen: recombinant protein
• Preparation and Storage: Store at 4 degree C after thawing.; Aliquot store at -20 degree C or -80 degree C.; Avoid repeated freeze/thaw cycles.

Western Blot (WB)

(Western Blot analysis of PAX9 on different lysates using anti-PAX9 antibody at 1/1,000 dilution. Positive control: Lane 1: HepG2 Lane 2: Hela)

Related Product Information for anti-PAX9 antibody

Pax genes contain paired domains with strong homology to genes in Droso-phila which are involved in programming early development. Pax-9, a member of the paired box-containing gene family, is closely related in its paired do-main to Pax-1. The Pax-9 gene encodes the highly conserved paired domain and the gene is a member of the same subgroup as Pax-1/undulated. Pax-9 is essential for the development of a variety of organs and skeletal elements. Mutations in either the Pax-1 or the Pax-9 genes may produce an inherited skeletal disorder such as the Jarcho-Levin syndrome or other forms of spondylocostal dysplasia, conditions resembling "undulated" in the mouse. A frameshift mutation within the paired domain of Pax-9 was identified in a family segregating autosomal dominant oligodontia whose members had normal primary dentition but lacked most permanent molars. In addition to lack of permanent molars, some individuals also lacked maxillary and/or mandibular second premolars, as well as mandibular central incisors. The gene which encodes Pax-9 maps to human chromosome 14q12-q13.

NCBI and Uniprot Product Information

• NCBI GI #: 1854514
• NCBI GeneID: 5083
• UniProt Accession #: P55771; P47242; Q2L4T2
• Molecular Weight: 36kDa
• NCBI Official Full Name: Pax9, partial
• NCBI Official Synonym Full Names: paired box 9
• NCBI Official Symbol: PAX9
• NCBI Official Synonym Symbols: STHAG3
• NCBI Protein Information: paired box protein Pax-9
• UniProt Protein Name: Paired box protein Pax-9
• Protein Family: Paired box protein
• UniProt Gene Name: PAX9
• UniProt Entry Name: PAX9_HUMAN

NCBI Description

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. Mice lacking this gene exhibit impaired development of organs, musculature and the skeleton, including absent and abnormally developed teeth, and neonatal lethality. Mutations in the human gene are associated with selective tooth agenesis-3. [provided by RefSeq, Sep 2015]

Uniprot Description

PAX9: Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. Interacts with KDM5B.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 14q13.3

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: odontogenesis; transcription, DNA-dependent; regulation of odontogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; endoderm development

Disease: Tooth Agenesis, Selective, 3