Rabbit anti-Human, Mouse MNX1 Polyclonal Antibody | anti-MNX1 antibody

MNX1, ID (MNX1, HLXB9, Motor neuron and pancreas homeobox protein 1, Homeobox protein HB9) (Azide free) (HRP)

Cat. Num. AAA6321552

• Gene Names: MNX1; HB9; HLXB9; SCRA1; HOXHB9
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: MNX1; Polyclonal Antibody; ID (MNX1; HLXB9; Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9) (Azide free) (HRP); Homeobox protein HB9; anti-MNX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-MNX1 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: MNX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-271 amino acids from the Central region of human MNX1.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(MNX1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow).)

Related Product Information for anti-MNX1 antibody

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Product Categories/Family for anti-MNX1 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Turgut, M. Acta Neurochir (Wien) 152(6):1083-1084(2010). Garcia-Barcelo, M.M., et al. J. Pediatr. Surg. 44(10):1892-1898(2009). Park, J., et al. Cancer Genet. Cytogenet. 191(2):102-105(2009). Ballabio, E., et al. Leukemia 23(6):1179-1182(2009). Taketani, T., et al. Cancer Genet. Cytogenet. 186(2):115-119(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 89257348
• NCBI GeneID: 3110
• NCBI Accession #: NP_005506.3
• NCBI GenBank Nucleotide #: NM_005515.3
• UniProt Accession #: P50219; Q9Y648; F5H401
• Molecular Weight: 20,553 Da
• NCBI Official Full Name: motor neuron and pancreas homeobox protein 1 isoform 1
• NCBI Official Synonym Full Names: motor neuron and pancreas homeobox 1
• NCBI Official Symbol: MNX1
• NCBI Official Synonym Symbols: HB9; HLXB9; SCRA1; HOXHB9
• NCBI Protein Information: motor neuron and pancreas homeobox protein 1
• UniProt Protein Name: Motor neuron and pancreas homeobox protein 1
• Protein Family: Motor neuron and pancreas homeobox protein
• UniProt Gene Name: MNX1
• UniProt Synonym Gene Names: HLXB9
• UniProt Entry Name: MNX1_HUMAN

NCBI Description

This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; dorsoventral neural tube patterning; humoral immune response; post-embryonic development

Disease: Currarino Syndrome