Western Blot (WB)
(MNX1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow).)
Rabbit anti-Human, mouse MNX1 Polyclonal Antibody | anti-MNX1 antibody
MNX1 Antibody (Center)
Western Blot (WB)
(MNX1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow).)
Western Blot (WB)
(MNX1 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the MNX1 antibody detected the MNX1 protein (arrow).)
homeobox domain and is a transcription factor. Mutations in this
gene result in Currarino syndrome, an autosomic dominant congenital
malformation. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Garcia-Barcelo, M.M., et al. J. Pediatr. Surg. 44(10):1892-1898(2009)
Park, J., et al. Cancer Genet. Cytogenet. 191(2):102-105(2009)
Ballabio, E., et al. Leukemia 23(6):1179-1182(2009)
Taketani, T., et al. Cancer Genet. Cytogenet. 186(2):115-119(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
MNX1: Putative transcription factor involved in pancreas development and function. Defects in MNX1 are a cause of Currarino syndrome (CURRAS). The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7q36
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; anatomical structure morphogenesis; transcription, DNA-dependent; spinal cord motor neuron cell fate specification; neuron migration; nerve development; motor axon guidance; endocrine pancreas development; humoral immune response; dorsoventral neural tube patterning; post-embryonic development
Disease: Currarino Syndrome
Research Articles on MNX1
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Product Notes
The MNX1 mnx1 (Catalog #AAA9200892) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 242-271. The MNX1 Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's MNX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the MNX1 mnx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MNX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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