Western Blot (WB)
(Western blot analysis of MnSOD pAb: Lane 1: HeLa Cell Lysate, Lane 2: Rat Brain Tissue Extract, Lane 3: Mouse Brain Tissue Extract)
Rabbit Mn SOD Polyclonal Antibody | anti-Manganese superoxide dismutase antibody
Mn SOD polyclonal antibody
Immunoprecipitation (1:100)
Western Blot (1:1,000, colorimetric)
Suggested dilutions/conditions may not be available for all applications.
Detects a band of ~25kDa by Western blot.
Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of MnSOD pAb: Lane 1: HeLa Cell Lysate, Lane 2: Rat Brain Tissue Extract, Lane 3: Mouse Brain Tissue Extract)
Western Blot (WB)
(Western blot analysis of MnSOD pAb: Lane 1: HeLa Cell Lysate, Lane 2: Rat Brain Tissue Extract, Lane 3: Mouse Brain Tissue Extract)
NCBI and Uniprot Product Information
NCBI Description
manganese superoxide dismutase; intramitochondrial free radical scavenging enzyme [RGD, Feb 2006]
Uniprot Description
SOD2: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the iron/manganese superoxide dismutase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; Mitochondrial; EC 1.15.1.1
Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; myelin sheath
Molecular Function: DNA binding; enzyme binding; identical protein binding; manganese ion binding; oxidoreductase activity; oxygen binding; superoxide dismutase activity
Biological Process: acetylcholine vasodilation involved in regulation of systemic arterial blood pressure; age-dependent response to oxidative stress; age-dependent response to reactive oxygen species; aging; apoptotic mitochondrial changes; detection of oxygen; DNA damage response, signal transduction resulting in induction of apoptosis; erythrophore differentiation; glutathione metabolic process; heart development; hemopoiesis; hydrogen peroxide biosynthetic process; hydrogen peroxide metabolic process; induction of apoptosis by oxidative stress; iron ion homeostasis; liver development; locomotory behavior; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of fibroblast proliferation; negative regulation of neuron apoptosis; neuron development; oxygen homeostasis; positive regulation of nitric oxide biosynthetic process; post-embryonic development; protein homooligomerization; protein homotetramerization; regulation of blood pressure; regulation of catalytic activity; regulation of mitochondrial membrane potential; regulation of transcription from RNA polymerase II promoter; release of cytochrome c from mitochondria; removal of superoxide radicals; response to activity; response to axon injury; response to cadmium ion; response to cold; response to drug; response to electrical stimulus; response to gamma radiation; response to hydrogen peroxide; response to hyperoxia; response to hypoxia; response to L-ascorbic acid; response to lipopolysaccharide; response to manganese ion; response to nutrient levels; response to oxidative stress; response to radiation; response to reactive oxygen species; response to selenium ion; response to silicon dioxide; response to superoxide; response to zinc ion; sensory perception of sound; superoxide metabolic process; superoxide release; vasodilation
Research Articles on Manganese superoxide dismutase
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Product Notes
The Manganese superoxide dismutase sod2 (Catalog #AAA565332) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mn SOD polyclonal antibody reacts with Human, Mouse, Rat, Bovine, Chicken, Clam, Dog, Drosophila, Guinea pig, Hamster, Monkey, Porcine, Rabbit, Sheep, Xenopus and may cross-react with other species as described in the data sheet. AAA Biotech's Mn SOD can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB). Flow Cytometry (1:100) Immunoprecipitation (1:100) Western Blot (1:1,000, colorimetric) Suggested dilutions/conditions may not be available for all applications. Detects a band of ~25kDa by Western blot. Researchers should empirically determine the suitability of the Manganese superoxide dismutase sod2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Mn SOD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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