Rabbit anti-Mouse, Rat mGluR5b Polyclonal Antibody | anti-GRM5 antibody

mGluR5b (Metabotropic Glutamate Receptor)

Cat. Num. AAA617792

• Gene Names: GRM5; mGlu5; GPRC1E; MGLUR5
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: mGluR5b; Polyclonal Antibody; mGluR5b (Metabotropic Glutamate Receptor); Anti -mGluR5b (Metabotropic Glutamate Receptor); anti-GRM5 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat mGluR5b (Metabotropic Glutamate Receptor). Species Reactivity: Mouse
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-glycine, 1% BSA, 0.1% sodium azide.

• Applicable Applications for anti-GRM5 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Western Blot: 1:1000
• Immunogen: Synthetic peptide corresponding to residues YDRRLAQHKSEIE of rat mGluR5b.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for anti-GRM5 antibody

Antibodies; Abs to G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 1408054
• NCBI GeneID: 2915
• UniProt Accession #: P41594; Q6J164
• Molecular Weight: 132,469 Da
• NCBI Official Full Name: Metabotropic Glutamate Receptor Subtype 5b
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 5
• NCBI Official Symbol: GRM5
• NCBI Official Synonym Symbols: mGlu5; GPRC1E; MGLUR5
• NCBI Protein Information: metabotropic glutamate receptor 5; OTTHUMP00000165953; OTTHUMP00000165956; OTTHUMP00000165957
• UniProt Protein Name: Metabotropic glutamate receptor 5
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM5
• UniProt Synonym Gene Names: GPRC1E; MGLUR5
• UniProt Entry Name: GRM5_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 3

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: integral to plasma membrane; postsynaptic density; cytoplasm; plasma membrane; dendritic spine; dendritic shaft

Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; A2A adenosine receptor binding

Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; locomotory behavior; learning; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation; synaptic transmission; negative regulation of locomotion; regulation of transcription, DNA-dependent; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; metabotropic glutamate receptor signaling pathway; activation of MAPKKK activity; cognition