Testing Data
(Image: mGluR5 immunoreactivity in rat globus pallidus. Images courtesy of Dr. Joyce Besheer, UNC.)
mGluR5 Antibody | anti-mGluR5 antibody
mGluR5, Affinity Purified Antibody, Rabbit
Testing Data
(Image: mGluR5 immunoreactivity in rat globus pallidus. Images courtesy of Dr. Joyce Besheer, UNC.)
Testing Data
(Image: mGluR5 immunoreactivity in rat globus pallidus. Images courtesy of Dr. Joyce Besheer, UNC.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; GPCR, family 3; Receptor, GPCR; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q14.3
Cellular Component: integral to plasma membrane; cytoplasm; postsynaptic density; plasma membrane; dendritic spine; dendritic shaft
Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; A2A adenosine receptor binding
Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; locomotory behavior; learning; positive regulation of long-term neuronal synaptic plasticity; protein amino acid phosphorylation; synaptic transmission; negative regulation of locomotion; regulation of transcription, DNA-dependent; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; metabotropic glutamate receptor signaling pathway; activation of MAPKKK activity; cognition
Research Articles on mGluR5
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Product Notes
The mGluR5 grm5 (Catalog #AAA555302) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The mGluR5, Affinity Purified Antibody, Rabbit reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's mGluR5 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the mGluR5 grm5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "mGluR5, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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