mGluR5 Protein | GRM5 protein

mGluR5 (Metabotropic Glutamate Receptor)

Cat. Num. AAA634906

• Gene Names: GRM5; mGlu5; GPRC1E; MGLUR5
• Reactivity: Mouse, Rat
• Synonyms: mGluR5; mGluR5 (Metabotropic Glutamate Receptor); GRM5 protein

• Reactivity: Mouse, Rat
• Form/Format: Supplied as a liquid.

• Application Notes: Suitable for use in Antibody Blocking.; Dilution: Antibody Blocking: 1:100 - 1:1000 1 hour at room temperature.
• Immunogen: Synthetic peptide corresponding to rat mGluR5 (Metabotropic Glutamate Receptor).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

(mGluR5 immunoreactivity in rat globus pallidus.)

Related Product Information for GRM5 protein

Metabotropic glutamate receptors have been classified into three groups. In general, class I receptors (mGluR1 and mGluR5) mediate the excitation of neurons, whereas activation of class II (mGluR2 and mGluR3) and class III (mGluR4a, mGluR7a, mGluR7b and mGluR8) results in a depression of synaptic transmission. Class I mGluRs are localized in the postsynaptic membrane and are positively coupled to phospholipase C (PLC). Class II and class III mGluRs localize to the presynaptic membrane and are negatively coupled to adenylate cyclase. It has been speculated that mGluR2 and/or mGluR3 may play a role in the modulation of the mossy terminal function.

Control Peptide for M3884-79D

Product Categories/Family for GRM5 protein

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4504143
• NCBI GeneID: 2915
• NCBI Accession #: NP_000833.1
• NCBI GenBank Nucleotide #: NM_000842.3
• UniProt Accession #: P41594; Q6J164
• Molecular Weight: 132,469 Da
• NCBI Official Full Name: metabotropic glutamate receptor 5 isoform b
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 5
• NCBI Official Symbol: GRM5
• NCBI Official Synonym Symbols: mGlu5; GPRC1E; MGLUR5
• NCBI Protein Information: metabotropic glutamate receptor 5; metabotropic glutamate receptor 5 variant F; metabotropic glutamate receptor 5 variant G; metabotropic glutamate receptor 5 variant H
• UniProt Protein Name: Metabotropic glutamate receptor 5
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM5
• UniProt Synonym Gene Names: GPRC1E; MGLUR5; mGluR5
• UniProt Entry Name: GRM5_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Uniprot Description

mGluR5: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 3; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: integral to plasma membrane; postsynaptic density; cytoplasm; dendritic spine; plasma membrane; dendritic shaft

Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; A2A adenosine receptor binding

Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; regulation of synaptic transmission, glutamatergic; locomotory behavior; learning; protein amino acid phosphorylation; positive regulation of long-term neuronal synaptic plasticity; synaptic transmission; negative regulation of locomotion; regulation of transcription, DNA-dependent; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; metabotropic glutamate receptor signaling pathway; activation of MAPKKK activity; cognition