Rabbit anti-Human, Mouse MED7 Polyclonal Antibody | anti-MED7 antibody

MED7 Antibody, FITC conjugated

Cat. Num. AAA1496535

• Gene Names: MED7; ARC34; CRSP9; CRSP33
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: MED7; Polyclonal Antibody; MED7 Antibody; FITC conjugated; Mediator of RNA polymerase II transcription subunit 7; hMED7; ARC34; CRSP9; Activator-recruited cofactor 34 kDa component; Cofactor required for Sp1 transcriptional activation subunit 9; CRSP complex subunit 9; Mediator complex subunit 7; RNA polymerase transcriptional regulation mediator subunit 7 homolog; Transcriptional coactivator CRSP33; anti-MED7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 233

• Applicable Applications for anti-MED7 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC
• Immunogen: Recombinant human Mediator of RNA polymerase II transcription subunit 7 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12457 / sc-9436
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-MED7 antibody

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

NCBI and Uniprot Product Information

• NCBI GI #: 155030188
• NCBI GeneID: 9443
• NCBI Accession #: NP_001094286.1
• NCBI GenBank Nucleotide #: NM_001100816.1
• UniProt Accession #: O43513
• Molecular Weight: 27,245 Da
• NCBI Official Full Name: mediator of RNA polymerase II transcription subunit 7
• NCBI Official Synonym Full Names: mediator complex subunit 7
• NCBI Official Symbol: MED7
• NCBI Official Synonym Symbols: ARC34; CRSP9; CRSP33
• NCBI Protein Information: mediator of RNA polymerase II transcription subunit 7
• UniProt Protein Name: Mediator of RNA polymerase II transcription subunit 7
• Protein Family: Putative mediator of RNA polymerase II transcription
• UniProt Gene Name: MED7
• UniProt Synonym Gene Names: ARC34; CRSP9; hMED7; ARC34; CRSP complex subunit 9
• UniProt Entry Name: MED7_HUMAN

NCBI Description

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

MED7: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 7 family.

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: nucleoplasm; Srb-mediator complex; transcription factor complex; ubiquitin ligase complex

Molecular Function: protein binding; transcription coactivator activity

Biological Process: gene expression; protein ubiquitination; regulation of transcription from RNA polymerase II promoter; stem cell maintenance; transcription initiation from RNA polymerase II promoter