Western Blot (WB)
(Western Blot: Sample: Lane1: Human Hela Cells; Lane2: Human Lung Tissue; Lane3: Porcine Stomach Tissue.)
Rabbit anti-Human Cytovillin (CVL) Polyclonal Antibody | anti-CVL antibody
Polyclonal Antibody to Cytovillin (CVL)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Lane1: Human Hela Cells; Lane2: Human Lung Tissue; Lane3: Porcine Stomach Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Human Hela Cells; Lane2: Human Lung Tissue; Lane3: Porcine Stomach Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CVL, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant CVL, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Prostate Gland Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue)
NCBI and Uniprot Product Information
NCBI Description
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3
Cellular Component: actin cytoskeleton; actin filament; apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border; cell body; cell periphery; cell projection; cortical cytoskeleton; cytoplasm; cytosol; endosome; extracellular exosome; extracellular space; extrinsic component of membrane; fibrillar center; filopodium; focal adhesion; immunological synapse; invadopodium; membrane; microspike; microvillus; microvillus membrane; myelin sheath; perinuclear region of cytoplasm; plasma membrane; protein complex; ruffle; T-tubule; TCR signalosome; uropod; vesicle
Molecular Function: actin binding; actin filament binding; ATPase binding; cadherin binding; cell adhesion molecule binding; microtubule binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase A binding; RNA binding; S100 protein binding
Biological Process: actin cytoskeleton reorganization; actin filament bundle formation; astral microtubule organization; axon guidance; cellular protein complex localization; cellular response to cAMP; cortical microtubule organization and biogenesis; cytoskeletal anchoring; D-glucose absorption; establishment of centrosome localization; establishment of epithelial cell apical/basal polarity; filopodium assembly; gland morphogenesis; leukocyte adhesion; membrane to membrane docking; microvillus assembly; negative regulation of ERK1 and ERK2 cascade; negative regulation of interleukin-2 secretion; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; phosphoinositide-mediated signaling; positive regulation of early endosome to late endosome transport; positive regulation of gene expression; positive regulation of multicellular organism growth; positive regulation of protein secretion; protein kinase A signaling; protein localization to plasma membrane; receptor internalization; regulation of actin cytoskeleton organization; regulation of cell shape; regulation of cell size; regulation of microvillus length; regulation of NIK/NF-kappaB signaling; regulation of organelle assembly; sphingosine-1-phosphate signaling pathway
Research Articles on CVL
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Product Notes
The CVL ezr (Catalog #AAA2013535) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Cytovillin (CVL) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cytovillin (CVL) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CVL ezr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLHYV DNKGFPTWLK LDKKVSAQEV RKENPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE VHKSGYLSSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR GMLKDNAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI. It is sometimes possible for the material contained within the vial of "Cytovillin (CVL), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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