Rabbit ME3 Polyclonal Antibody | anti-ME3 antibody

ME3 Polyclonal Antibody

Cat. Num. AAA2565408

• Gene Names: ME3; NADP-ME
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence
• Purity: Affinity purification
• Synonyms: ME3; Polyclonal Antibody; ME3 Polyclonal Antibody; NADP-ME; anti-ME3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1mg/mL (varies by lot)

• Applicable Applications for anti-ME3 antibody: Immunofluorescence (IF)
• Application Notes: IF: 1:50-1:200
• Immunogen: Recombinant fusion protein of human ME3 (NP_0010148111)
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunofluorescence (IF)

(Immunofluorescence analysis of L929 cells using ME3 Polyclonal Antibody at dilution of 1:100. Blue: DAPI for nuclear staining.)

Related Product Information for anti-ME3 antibody

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP (+)-dependent isoform, a mitochondrial NADP (+)-dependent isoform, and a mitochondrial NAD (+)-dependent isoform. This gene encodes a mitochondrial NADP (+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Product Categories/Family for anti-ME3 antibody

Cell Biology; Metabolism; Signal Transduction; Polyclonal Antibody

NCBI and Uniprot Product Information

• NCBI GI #: 62420882
• NCBI GeneID: 10873
• NCBI Accession #: NP_001014811.1
• NCBI GenBank Nucleotide #: NM_001014811.1
• UniProt Accession #: Q16798
• Molecular Weight: 67,068 Da
• NCBI Official Full Name: NADP-dependent malic enzyme, mitochondrial
• NCBI Official Synonym Full Names: malic enzyme 3, NADP(+)-dependent, mitochondrial
• NCBI Official Symbol: ME3
• NCBI Official Synonym Symbols: NADP-ME
• NCBI Protein Information: NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase; pyruvic-malic carboxylase; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3
• UniProt Protein Name: NADP-dependent malic enzyme, mitochondrial
• UniProt Gene Name: ME3
• UniProt Synonym Gene Names: NADP-ME
• UniProt Entry Name: MAON_HUMAN

NCBI Description

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

ME3: Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Oxidoreductase; Mitochondrial; EC 1.1.1.40; Carbohydrate Metabolism - pyruvate

Chromosomal Location of Human Ortholog: 11cen-q22.3

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: malate dehydrogenase (decarboxylating) activity; malic enzyme activity; metal ion binding; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity; cofactor binding; NAD binding; oxaloacetate decarboxylase activity

Biological Process: malate metabolic process; aerobic respiration; pyruvate metabolic process