Western Blot (WB)
(MARCKSL1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MARCKSL1 antibody detected the MARCKSL1 protein (arrow).)
Rabbit anti-Human MARCKSL1 Polyclonal Antibody | anti-MARCKSL1 antibody
MARCKSL1, CT (MARCKSL1, MLP, MRP, MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(MARCKSL1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MARCKSL1 antibody detected the MARCKSL1 protein (arrow).)
Western Blot (WB)
(MARCKSL1 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MARCKSL1 antibody detected the MARCKSL1 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
Uniprot Description
Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems
By similarity.
Subunit structure: Binds to filamentous actin (F-actin), but not to monomeric G-actin, independently of its phosphorylation status
By similarity.
Subcellular location: Cytoplasm
By similarity. Cell membrane
By similarity. Note: Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca2+/calmodulin
By similarity. In prostate cancers, detected in the cytoplasm and associated with apical or basal membranes
By similarity.
Post-translational modification: Phosphorylation at Ser-120 and Thr-178 are non-redundantly catalyzed by MAPK8 in vivo. Phosphorylation at Thr-148 is preferentially catalyzed by MAPK8 in vivo, but this modification can also be catalyzed by other kinases in the absence of MAPK8
By similarity.
Sequence similarities: Belongs to the MARCKS family.
Research Articles on MARCKSL1
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Product Notes
The MARCKSL1 marcksl1 (Catalog #AAA647650) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MARCKSL1, CT (MARCKSL1, MLP, MRP, MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MARCKSL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the MARCKSL1 marcksl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MARCKSL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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