Rabbit MAP3K12 Polyclonal Antibody | anti-MAP3K12 antibody

MAP3K12 Antibody

Cat. Num. AAA9411340

• Gene Names: MAP3K12; DLK; MUK; ZPK; ZPKP1; MEKK12
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: MAP3K12; Polyclonal Antibody; MAP3K12 Antibody; DLK; MUK; ZPK; ZPKP1; MEKK12; anti-MAP3K12 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total MAP3K12 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 1.4 mg/ml (varies by lot)
• Sequence Length: 892

• Applicable Applications for anti-MAP3K12 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:100
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human mitogen-activated protein kinase kinase kinase 12
• Target Name: MAP3K12
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/30.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.)

Related Product Information for anti-MAP3K12 antibody

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Product Categories/Family for anti-MAP3K12 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 301898343
• NCBI GeneID: 7786
• NCBI Accession #: NP_001180440.1
• NCBI GenBank Nucleotide #: NM_001193511.1
• UniProt Accession #: Q12852; Q86VQ5; Q8WY25; B3KSS9; G3V1Y2
• Molecular Weight: 96,322 Da
• NCBI Official Full Name: mitogen-activated protein kinase kinase kinase 12 isoform 1
• NCBI Official Synonym Full Names: mitogen-activated protein kinase kinase kinase 12
• NCBI Official Symbol: MAP3K12
• NCBI Official Synonym Symbols: DLK; MUK; ZPK; ZPKP1; MEKK12
• NCBI Protein Information: mitogen-activated protein kinase kinase kinase 12
• UniProt Protein Name: Mitogen-activated protein kinase kinase kinase 12
• Protein Family: MAP3K12-binding inhibitory protein
• UniProt Gene Name: MAP3K12
• UniProt Synonym Gene Names: ZPK; DLK; ZPK; MUK
• UniProt Entry Name: M3K12_HUMAN

NCBI Description

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]

Uniprot Description

DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Protein type: Kinase, protein; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; MLK family; LZK subfamily

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: growth cone; membrane; axon; cytoplasm; plasma membrane; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; MAP kinase kinase kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: peptidyl-serine phosphorylation; activation of MAPKK activity; protein amino acid autophosphorylation; histone phosphorylation; peptidyl-threonine phosphorylation; JNK cascade; protein amino acid phosphorylation