Rabbit anti-Human Lysozyme Polyclonal Antibody | anti-Lzm antibody

Lysozyme

Cat. Num. AAA373032

• Gene Names: Lzm; BmLys
• Reactivity: Human
• Synonyms: Lysozyme; Polyclonal Antibody; anti-Lzm antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Lysozyme is a purified immunoglobulin fraction of rabbit antiserum that is filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

• Control: Tonsil, Lymph Node
• Localization: Cytoplasmic
• Reactivity Note: Paraffin, Frozen
• Preparation and Storage: Store at 2 to 8 degree C in the dark.

Dilution Information

Immunohistochemistry (IHC)

Related Product Information for anti-Lzm antibody

Lysozyme is a 14.4 kDa enzyme, commonly referred to as the "body's own antibiotic" since it kills bacteria. Lysozyme is an enzyme that destroys bacterial cell walls by hydrolyzing the polysaccharide component of the cell wall. It is abundantly present in a number of secretions, including tears. This protein is present in cytoplasmic granules of the polymorphonuclear neutrophils (PMN) and released through mucosal secretions such as tears and saliva. They can also be found in high concentration in egg white. Lysozyme stains myeloid cells, histiocytes, granulocytes, macrophages, and monocytes in human tonsil, colon and skin. It is an important marker that may demonstrate the myeloid or monocytic nature of Acute Leukemia. The restrictive nature of Lysozyme antibody staining suggests that Lysozyme may be synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. It has not been determined whether Lysozyme stains any other cell or tissue type. Lysozyme may aid in the identification of histiocytic neoplasias and large lymphocytes, as well as classifying lymphoproliferative disorders.

NCBI and Uniprot Product Information

• NCBI GI #: 112984208
• NCBI GeneID: 693015
• NCBI Accession #: NP_001037448.1
• NCBI GenBank Nucleotide #: NM_001043983.1
• UniProt Accession #: P48816; Q9TWL7
• Molecular Weight: 13648 Da
• NCBI Official Full Name: lysozyme
• NCBI Official Symbol: Lzm
• NCBI Official Synonym Symbols: BmLys
• NCBI Protein Information: lysozyme; 1,4-beta-N-acetylmuramidase
• UniProt Protein Name: Lysozyme
• Protein Family: Lysozyme
• UniProt Entry Name: LYS_BOMMO

Uniprot Description

Function: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Active against E.coli and M.luteus. Ref.2

Catalytic activity: Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Developmental stage: Expressed within 6 hours after induction, reaches maximum levels after 48 hours and declines after 72 hours after induction.

Induction: By bacterial infection.

Sequence similarities: Belongs to the glycosyl hydrolase 22 family.